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<p>Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) cases are diagnosed at advanced stages, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients requiring aggressive treatment is crucial. We present mutational, transcriptomic, and proteomic studies of 103 Chinese HPSCC patients and observe a higher prevalence and poorer prognosis in males. Estrogen response pathways are up-regulated, and proteins phosphorylated by protein kinase C (PKC) and cyclin-dependent kinases (CDKs) are aberrantly regulated in HPSCC. We identify aberrant copy number regions including <i>SOX2</i>(3q26.33), <i>FGFR</i>(8p11.23), <i>CCND1</i>(11q13.3), <i>CDKN2A/2B</i>(9p21.3), and <i>MYC</i>(8q24.21). Human papillomavirus (HPV) status combined with highly mutated genes, such as <i>SYNE1</i> in HPV(−) and <i>MUC4</i> in HPV(+) patients, were assessed as prognosis markers. A predictive model involving clinical factors and expression of six genes was established and cross-site validated. These findings open new opportunities for stratifying high-risk patients and molecular targets for personalized therapeutic strategies.</p>

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Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月5日

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  • Yanxin Ren,
  • Wei Xiong,
  • Chun Feng,
  • Dan Yu,
  • Xiaoyan Wang,
  • Qing Yang,
  • Siting Yu,
  • Hongjiang Zhang,
  • Bangyun Huo,
  • Honglu Jiang,
  • Zuli Li,
  • Junlin Wang,
  • Yu-Xiong Su,
  • Ping Yang,
  • Yong Liao,
  • Qi Zhong,
  • Junwen Wang

摘要

Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) cases are diagnosed at advanced stages, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients requiring aggressive treatment is crucial. We present mutational, transcriptomic, and proteomic studies of 103 Chinese HPSCC patients and observe a higher prevalence and poorer prognosis in males. Estrogen response pathways are up-regulated, and proteins phosphorylated by protein kinase C (PKC) and cyclin-dependent kinases (CDKs) are aberrantly regulated in HPSCC. We identify aberrant copy number regions including SOX2(3q26.33), FGFR(8p11.23), CCND1(11q13.3), CDKN2A/2B(9p21.3), and MYC(8q24.21). Human papillomavirus (HPV) status combined with highly mutated genes, such as SYNE1 in HPV(−) and MUC4 in HPV(+) patients, were assessed as prognosis markers. A predictive model involving clinical factors and expression of six genes was established and cross-site validated. These findings open new opportunities for stratifying high-risk patients and molecular targets for personalized therapeutic strategies.