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<p>Digital therapeutics (DTx) are increasingly established, yet their mechanisms of action (MoA) remain underexplored. This article defines and categorizes DTx MoA through a novel conceptual framework, distinguishing them from conventional treatments. We specifically conceptualize therapeutic elements, cognitive-affective and behavioral changes, and segment the notion of “dose” into distinct categories. This actionable framework provides a systematic basis for enhancing DTx research, design, and clinical effectiveness.</p>

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Mechanisms of action for digital therapeutics

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月5日

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  • Linea Schmidt,
  • Benedikt Langenberger,
  • Felix Schirmann,
  • Simon Reif,
  • Ariel Dora Stern

摘要

Digital therapeutics (DTx) are increasingly established, yet their mechanisms of action (MoA) remain underexplored. This article defines and categorizes DTx MoA through a novel conceptual framework, distinguishing them from conventional treatments. We specifically conceptualize therapeutic elements, cognitive-affective and behavioral changes, and segment the notion of “dose” into distinct categories. This actionable framework provides a systematic basis for enhancing DTx research, design, and clinical effectiveness.