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<p>Diagnostic rules are codified in consensus manuals such as DSM-5, yet they remain written in narrative form and cannot be computationally interrogated. Here, a deterministic framework is presented that translates diagnostic criteria into a machine-actionable representation of the full symptom space, which can be charted, navigated, and systematically analyzed. Unlike probabilistic models that infer patterns from large textual corpora, this framework directly interrogates explicit consensus criteria, providing a transparent and reproducible means of assessing conceptual coherence. Its potential is demonstrated by charting schizophrenia-spectrum disorders, which remain conceptually distinct despite substantial symptom overlap, and by evaluating the current National Academies’ definition of Long COVID, which is largely subsumed by depressive and anxiety disorders. By making diagnostic consensus computable, the framework provides a reproducible foundation for evaluating delineation properties of existing and candidate diagnostic constructs and for developing interpretable, regulatory-compliant diagnostic support tools.</p>

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Machine-actionable criteria chart the symptom space of mental disorders

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月23日

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  • Barbara Strasser-Kirchweger,
  • Raoul Hugo Kutil,
  • Georg Zimmermann,
  • Christian Borgelt,
  • Wolfgang Trutschnig,
  • Florian Hutzler

摘要

Diagnostic rules are codified in consensus manuals such as DSM-5, yet they remain written in narrative form and cannot be computationally interrogated. Here, a deterministic framework is presented that translates diagnostic criteria into a machine-actionable representation of the full symptom space, which can be charted, navigated, and systematically analyzed. Unlike probabilistic models that infer patterns from large textual corpora, this framework directly interrogates explicit consensus criteria, providing a transparent and reproducible means of assessing conceptual coherence. Its potential is demonstrated by charting schizophrenia-spectrum disorders, which remain conceptually distinct despite substantial symptom overlap, and by evaluating the current National Academies’ definition of Long COVID, which is largely subsumed by depressive and anxiety disorders. By making diagnostic consensus computable, the framework provides a reproducible foundation for evaluating delineation properties of existing and candidate diagnostic constructs and for developing interpretable, regulatory-compliant diagnostic support tools.