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<p>Patients with unstable pelvic fractures combined with traumatic brain injury (TBI) present complex conditions, with pathophysiological contradictions in clinical treatment between limited fluid resuscitation and maintenance of cerebral perfusion pressure. A retrospective analysis was conducted on 204 patients with unstable pelvic fractures combined with TBI between January 1, 2010, and May 31, 2025. A Nomogram model was constructed via LASSO and multivariate logistic regression, with simultaneous development of an interpretable machine learning prediction model. Results identified shock, abnormal systolic blood pressure (SBP), non-surgical management, and prolonged coagulation time as independent poor prognosis risk factors. The Nomogram constructed using SBP, shock, pelvic fracture surgery, and prothrombin time (PT), showed good performance (AUC = 0.801, C-index = 0.7747). Poor prognosis risk was lowest at SBP 110–122 mmHg; a U-shaped correlation existed between SBP and prognosis. The Nomogram and interpretable XGBoost model provide a basis for individualized blood pressure management, coagulation monitoring, and surgical decision-making. ChiCTR2500103926, registered on May 9, 2025, PID: 275507</p>

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Prognostic model and U-shaped SBP-risk correlation in unstable pelvic fractures with TBI

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月16日

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  • Shuming Du,
  • Xiaolong Zheng,
  • Yaxu Zhang,
  • Qiang Xiang,
  • Changgui Zhang

摘要

Patients with unstable pelvic fractures combined with traumatic brain injury (TBI) present complex conditions, with pathophysiological contradictions in clinical treatment between limited fluid resuscitation and maintenance of cerebral perfusion pressure. A retrospective analysis was conducted on 204 patients with unstable pelvic fractures combined with TBI between January 1, 2010, and May 31, 2025. A Nomogram model was constructed via LASSO and multivariate logistic regression, with simultaneous development of an interpretable machine learning prediction model. Results identified shock, abnormal systolic blood pressure (SBP), non-surgical management, and prolonged coagulation time as independent poor prognosis risk factors. The Nomogram constructed using SBP, shock, pelvic fracture surgery, and prothrombin time (PT), showed good performance (AUC = 0.801, C-index = 0.7747). Poor prognosis risk was lowest at SBP 110–122 mmHg; a U-shaped correlation existed between SBP and prognosis. The Nomogram and interpretable XGBoost model provide a basis for individualized blood pressure management, coagulation monitoring, and surgical decision-making. ChiCTR2500103926, registered on May 9, 2025, PID: 275507