Scholarlink

<p>Electrolyte-gated organic transistors (EGOTs) can be operated as sensors with high selectivity and an outstandingly low limit of detection. Their response to interfacial interactions occurs either by capacitive coupling between gate and channel or by faradaic reactions. In this work, we endow a high-affinity sensing response to EGOTs based on the PEDOT:PSS channel by functionalization of the gate electrode with Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub> MXenes. MXene were synthesized in different conditions to tailor surface chemistry, while retaining a similar skeleton structure. The integration of MXene-based functionalization layers is shown to preserve the high transconductance in EGOT devices, while simultaneously tuning the switch-on voltage toward 0 V. This modulation enables a safe operational window in aqueous electrolytes, preventing unwanted electrochemical side reactions. We then demonstrated that EGOT with the surface-tailored MXene layers are sensitive to concentrations of the neurotransmitter dopamine down to sub-picomolar levels of detection. These unprecedented LODs indicate that modification of EGOTs gate with tailored or functionalized MXenes is a viable and versatile strategy to enhance sensitivity to relevant biomarkers.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sub-picomolar dopamine sensing in aqueous electrolyte with surface-engineered MXene-gated organic transistors

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月19日

查看全文
  • Matteo Genitoni,
  • Ioan-Alexandru Baragau,
  • Matteo Sensi,
  • Dana Georgeta Popescu,
  • George E. Stan,
  • Petru Palade,
  • Outman El Khouja,
  • Sabina Alexandra Nicolae,
  • Alice Lunghi,
  • Pierpaolo Greco,
  • Michele Bianchi,
  • Fabio Biscarini

摘要

Electrolyte-gated organic transistors (EGOTs) can be operated as sensors with high selectivity and an outstandingly low limit of detection. Their response to interfacial interactions occurs either by capacitive coupling between gate and channel or by faradaic reactions. In this work, we endow a high-affinity sensing response to EGOTs based on the PEDOT:PSS channel by functionalization of the gate electrode with Ti3C2TX MXenes. MXene were synthesized in different conditions to tailor surface chemistry, while retaining a similar skeleton structure. The integration of MXene-based functionalization layers is shown to preserve the high transconductance in EGOT devices, while simultaneously tuning the switch-on voltage toward 0 V. This modulation enables a safe operational window in aqueous electrolytes, preventing unwanted electrochemical side reactions. We then demonstrated that EGOT with the surface-tailored MXene layers are sensitive to concentrations of the neurotransmitter dopamine down to sub-picomolar levels of detection. These unprecedented LODs indicate that modification of EGOTs gate with tailored or functionalized MXenes is a viable and versatile strategy to enhance sensitivity to relevant biomarkers.