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<p>Many cancer therapies achieve durable control without complete tumor eradication, suggesting that disrupting tumor organization may be more critical than killing cells. We propose that effective treatments converge by destabilizing the tumor’s Group Phenotypic Composition (GPC), the functional and spatial organization of interacting cell populations. When this organization collapses, tumors lose coherence. This perspective provides a unifying framework for designing therapies targeting tumor-level dynamics rather than cell number alone.</p>

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When effective anticancer therapies are, in fact, destabilizing the tumor’s Group Phenotypic Composition

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Frédéric Thomas,
  • Antoine M. Dujon,
  • Andriy Marusyk,
  • James DeGregori,
  • Alexandre Fontanella,
  • Margaux Bieuville,
  • Mario Campone,
  • Pascal Pujol,
  • Catherine Alix-Panabières,
  • Laurent Lecam,
  • Benjamin Roche,
  • Matthieu Lacroix,
  • Christophe Hirtz,
  • Laurent Poulain,
  • Jean-Pascal Capp,
  • Beata Ujvari,
  • Jordan Meliani,
  • Robert Noble,
  • Aurora M. Nedelcu,
  • Robert Gatenby

摘要

Many cancer therapies achieve durable control without complete tumor eradication, suggesting that disrupting tumor organization may be more critical than killing cells. We propose that effective treatments converge by destabilizing the tumor’s Group Phenotypic Composition (GPC), the functional and spatial organization of interacting cell populations. When this organization collapses, tumors lose coherence. This perspective provides a unifying framework for designing therapies targeting tumor-level dynamics rather than cell number alone.