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<p>Classification of benign, borderline, and malignant adnexal masses is critical to effective clinical management, but remains a challenge. We developed Clinical-Ovarian Multi-Task Attention (Clinical-OMTA), an artificial intelligence model based on a dual-backbone architecture (benign vs. non-benign, and borderline vs. malignant) that integrates ultrasound, age, and Carbohydrate Antigen 125 (CA125) for multi-class classification. The model’s performance, generalisability, and clinical utility were evaluated. Retrospective data were collected from 23 hospitals (1882 patients for training, validation, and internal testing from 21 hospitals; 340 and 159 patients for external testing from two hospitals). In the external image dataset, Clinical-OMTA demonstrated comparable diagnostic performance to ADNEX (area under the receiver operating characteristic curve [AUC]: 0.950 vs. 0.953, 0.870 vs. 0.853, 0.930 vs. 0.938) and subjective assessment by an expert examiner (accuracy: 85.6% vs. 87.4%). While Clinical-OMTA supported multimodal integration, it did not outperform Ovarian Multi-Task Attention (OMTA) that trained only with images, indicating that including age and CA125 did not improve performance. Clinical-OMTA performed similarly across acquisition modes, equipment types, scanning methods, and different centres (accuracy: 79.9%–87.7%). With Clinical-OMTA as a decision support tool, radiologists showed significantly improved inter-reader agreement (kappa: 0.17–0.78 vs. 0.86–0.98) and diagnostic accuracy (72.3% vs. 88.0%). Clinical-OMTA appears generalisable and could be especially useful in low-resource or remote settings where expert ultrasound examiners are scarce.</p>

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Development and validation of an artificial intelligence-based model for diagnosing benign, borderline, and malignant adnexal masses

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月3日

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  • Yingnan Wu,
  • Wenli Dai,
  • Xiaoying Li,
  • Shuang Zhang,
  • Liping Gong,
  • Jin Wang,
  • Ailin Cui,
  • Songxue Li,
  • Manning Zhu,
  • Shuang Dong,
  • Yaoting Wang,
  • Lei Zhou,
  • Dexing Kong,
  • Jing Zhao,
  • Litao Sun

摘要

Classification of benign, borderline, and malignant adnexal masses is critical to effective clinical management, but remains a challenge. We developed Clinical-Ovarian Multi-Task Attention (Clinical-OMTA), an artificial intelligence model based on a dual-backbone architecture (benign vs. non-benign, and borderline vs. malignant) that integrates ultrasound, age, and Carbohydrate Antigen 125 (CA125) for multi-class classification. The model’s performance, generalisability, and clinical utility were evaluated. Retrospective data were collected from 23 hospitals (1882 patients for training, validation, and internal testing from 21 hospitals; 340 and 159 patients for external testing from two hospitals). In the external image dataset, Clinical-OMTA demonstrated comparable diagnostic performance to ADNEX (area under the receiver operating characteristic curve [AUC]: 0.950 vs. 0.953, 0.870 vs. 0.853, 0.930 vs. 0.938) and subjective assessment by an expert examiner (accuracy: 85.6% vs. 87.4%). While Clinical-OMTA supported multimodal integration, it did not outperform Ovarian Multi-Task Attention (OMTA) that trained only with images, indicating that including age and CA125 did not improve performance. Clinical-OMTA performed similarly across acquisition modes, equipment types, scanning methods, and different centres (accuracy: 79.9%–87.7%). With Clinical-OMTA as a decision support tool, radiologists showed significantly improved inter-reader agreement (kappa: 0.17–0.78 vs. 0.86–0.98) and diagnostic accuracy (72.3% vs. 88.0%). Clinical-OMTA appears generalisable and could be especially useful in low-resource or remote settings where expert ultrasound examiners are scarce.