Scholarlink

<p>Pancreatic adenocarcinoma remains one of the most devastating cancers, with limited options for early diagnosis and outcome prediction. To address these gaps, we prospectively characterized circulating tumor cells (CTCs) and oncosomes from both the peripheral (PB) and portal vein (PoVB). A total of 121 blood samples from 39 patients (75 PB, 46 PoVB) undergoing endoscopic ultrasound were profiled using multiplex immunofluorescence and computational algorithms for rare event detection. Rare event counts were significantly elevated in pancreatic cancer patients compared to normal donors (<i>p</i> = 4.71e-10). PoVB yielded greater numbers of epithelial and mesenchymal CTCs compared to PB, suggesting restricted systemic entry, while oncosomes were consistently detected in both compartments. Diagnostic accuracy was highest for PB oncosomes and PoVB CTCs. Importantly, PoVB mesenchymal CTCs correlated with 1-year survival (<i>p</i> = 0.0083), and PB oncosomes predicted poor survival (<i>p</i> = 0.0014). These findings highlight complementary diagnostic and prognostic value of PB oncosomes and PoVB CTCs in pancreatic cancer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Circulating tumor cell and oncosome subtypes in portal and peripheral venous circulations may be used for diagnosis and prognostication of pancreatic cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月5日

查看全文
  • Stephanie N. Shishido,
  • Divya Suresh,
  • Jeremy Mason,
  • Quin Liu,
  • Kenneth Park,
  • Rabindra Watson,
  • Nicholas Nissen,
  • Srinivas Gaddam,
  • Simon K. Lo,
  • Stephen Pandol,
  • Peter Kuhn

摘要

Pancreatic adenocarcinoma remains one of the most devastating cancers, with limited options for early diagnosis and outcome prediction. To address these gaps, we prospectively characterized circulating tumor cells (CTCs) and oncosomes from both the peripheral (PB) and portal vein (PoVB). A total of 121 blood samples from 39 patients (75 PB, 46 PoVB) undergoing endoscopic ultrasound were profiled using multiplex immunofluorescence and computational algorithms for rare event detection. Rare event counts were significantly elevated in pancreatic cancer patients compared to normal donors (p = 4.71e-10). PoVB yielded greater numbers of epithelial and mesenchymal CTCs compared to PB, suggesting restricted systemic entry, while oncosomes were consistently detected in both compartments. Diagnostic accuracy was highest for PB oncosomes and PoVB CTCs. Importantly, PoVB mesenchymal CTCs correlated with 1-year survival (p = 0.0083), and PB oncosomes predicted poor survival (p = 0.0014). These findings highlight complementary diagnostic and prognostic value of PB oncosomes and PoVB CTCs in pancreatic cancer.