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<p>MET protein (also known as c-Met protein) overexpression (OE) is an emerging clinically relevant biomarker that is targetable with antibody-drug conjugates. c-Met protein’s prevalence varies, depending on the different OE thresholds, antibodies, and detection methodologies used. Unlike <i>MET</i> genomic aberrations, MET protein OE is a protein biomarker requiring immunohistochemistry (IHC)-based testing. Herein, we summarize the current evidence on MET protein OE, including prognostic value, heterogeneity, and stability. We also provide key considerations for enabling optimal real-world testing of this IHC-based biomarker.</p>

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MET (c-Met) protein overexpression is an emerging protein biomarker in non-small cell lung cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月20日

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  • Ming-Sound Tsao,
  • Lynette Sholl,
  • Michelle Shiller,
  • Peter Illei,
  • Ignacio I. Wistuba,
  • Mary Beth Beasley,
  • Kurt A. Schalper,
  • Archana Simmons,
  • Peter Ansell,
  • Sue Beruti,
  • Mari Mino-Kenudson

摘要

MET protein (also known as c-Met protein) overexpression (OE) is an emerging clinically relevant biomarker that is targetable with antibody-drug conjugates. c-Met protein’s prevalence varies, depending on the different OE thresholds, antibodies, and detection methodologies used. Unlike MET genomic aberrations, MET protein OE is a protein biomarker requiring immunohistochemistry (IHC)-based testing. Herein, we summarize the current evidence on MET protein OE, including prognostic value, heterogeneity, and stability. We also provide key considerations for enabling optimal real-world testing of this IHC-based biomarker.