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<p>Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes. Gene fusions involving the immunoglobulin heavy chain gene represent a complex and diverse category. These fusions often result in enhancer hijacking, upregulation of partner proto-oncogenes and contribute to leukemogenesis. This review highlights the mechanisms underlying <i>IGH</i> gene fusions, the critical role they play in ALL pathogenesis, and current detection technologies.</p>

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Deciphering IGH rearrangement complexity and detection strategies in acute lymphoblastic leukaemia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月4日

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  • Ashlee Thomson,
  • Jacqueline Rehn,
  • David Yeung,
  • James Breen,
  • Deborah White

摘要

Acute lymphoblastic leukaemia is a highly heterogeneous malignancy characterised by various genomic alterations that influence disease progression and therapeutic outcomes. Gene fusions involving the immunoglobulin heavy chain gene represent a complex and diverse category. These fusions often result in enhancer hijacking, upregulation of partner proto-oncogenes and contribute to leukemogenesis. This review highlights the mechanisms underlying IGH gene fusions, the critical role they play in ALL pathogenesis, and current detection technologies.