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<p>Mice have been used as models of urinary tract infection (UTI) for decades and laid the basis for the fundamental understanding of UTI pathogenesis in humans. Here we report that the high urine osmolarity of mice impacts key aspects of <i>Escherichia coli</i> UTI pathogenesis and represents a confounder for the translation of results to humans.</p>

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Hyperosmolarity of mouse urine confounds research in urinary tract infection

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月29日

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  • Kristian Stærk,
  • Janni Søvsø Hjelmager,
  • Rasmus Birkholm Grønnemose,
  • Marie Lykke Bach,
  • Jens Sivkær Pettersen,
  • Thomas Emil Andersen

摘要

Mice have been used as models of urinary tract infection (UTI) for decades and laid the basis for the fundamental understanding of UTI pathogenesis in humans. Here we report that the high urine osmolarity of mice impacts key aspects of Escherichia coli UTI pathogenesis and represents a confounder for the translation of results to humans.