Scholarlink

<p>The reduced pathogenicity of early SARS-CoV-2 Omicron subvariants in human ACE2-expressing K18-hACE2 mice has posed challenges for assessing vaccine and antiviral efficacy against the Omicron variant with the mouse model. Here we report the enhanced pathogenicity of the Omicron JN.1 and EG.5 lineages in K18-hACE2 mice compared with their ancestors, suggesting the potential of applying these Omicron lineages in the mouse infection model.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

SARS-CoV-2 Omicron EG.5 and JN.1 induce enhanced pathogenicity in K18-hACE2 mice compared with the early Omicron subvariants

  • 期刊论文

  • 发表日期：

    2026年3月19日

查看全文
  • Mandy Tsoi Man Ho,
  • Nigeer Te,
  • Kenrie Pui Yan Hui,
  • Rachel Hiu Ha Ching,
  • John Chi Wang Ho,
  • Samuel Mo Sheung Cheng,
  • John Malcolm Nicholls,
  • Michael Chi Wai Chan,
  • Leo Lit Man Poon,
  • Alex Wing Hong Chin

摘要

The reduced pathogenicity of early SARS-CoV-2 Omicron subvariants in human ACE2-expressing K18-hACE2 mice has posed challenges for assessing vaccine and antiviral efficacy against the Omicron variant with the mouse model. Here we report the enhanced pathogenicity of the Omicron JN.1 and EG.5 lineages in K18-hACE2 mice compared with their ancestors, suggesting the potential of applying these Omicron lineages in the mouse infection model.