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<p>Perforated bacterial keratitis requires intensive topical antibiotic administration combined with bandage contact lens placement and cyanoacrylate glue application, yet conventional eye drops suffer from poor ocular retention and low bioavailability. For this reason, this study developed extemporaneous dual-drug-loaded therapeutic contact lenses containing ceftazidime and cefazolin using two commercial contact lenses of Biomedic<sup>®</sup> 1&#xa0;day Plus (Ocufilcon D; poly(2-hydroxyethyl methacrylate)/methacrylic acid, pHEMA/MAA) and Precision 1<sup>®</sup> 1-Day (Verofilcon A; silicone hydrogel). Using a simple soaking method, the Biomedic lenses exhibited markedly higher loading capacities (up to ~ 40–45&#xa0;mg per lens) and adsorption efficiencies (~ 50–60%) compared with Precision lenses (&lt; 20 mg; &lt;40%), attributable to the hydrophilic pHEMA/MAA network that enables hydrogen bonding and electrostatic interactions with β-lactam antibiotics. Scanning electron microscopy showed that the Biomedic lenses had more porosity than the Precision lenses, re-confirming the higher drug loading. FT-IR spectroscopy confirmed non-covalent drug incorporation and the drugs were adsorbed in molecular dispersion forms. Both drug-loaded lenses maintained high optical transparency (&gt; 80% transmittance), indicating suitability for therapeutic wear. <i>In vitro</i> release studies revealed biphasic kinetics with an initial burst followed by sustained diffusion-controlled release, with Biomedic lenses showed more prolonged release than the Precision 1 lenses. Conclusively, the developed system, especially the dual-drug-loaded Biomedic lenses, could represent a promising localized drug-delivery strategy to enhance ocular residence time, reduce dosing frequency, and improve management of perforated bacterial keratitis.</p>

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Extemporaneous dual-drug-loaded contact lenses containing ceftazidime and cefazolin for perforated bacterial keratitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Pratthana Chomchalao,
  • Phuong T.M. Ha,
  • Tran Thi Ngoc Linh,
  • Phuong Nhut Khanh,
  • Ngoc Yen Nguyen,
  • Aphiradee Boonkham,
  • Waree Tiyaboonchai,
  • Rossukon Khotcharrat,
  • Duy Toan Pham

摘要

Perforated bacterial keratitis requires intensive topical antibiotic administration combined with bandage contact lens placement and cyanoacrylate glue application, yet conventional eye drops suffer from poor ocular retention and low bioavailability. For this reason, this study developed extemporaneous dual-drug-loaded therapeutic contact lenses containing ceftazidime and cefazolin using two commercial contact lenses of Biomedic® 1 day Plus (Ocufilcon D; poly(2-hydroxyethyl methacrylate)/methacrylic acid, pHEMA/MAA) and Precision 1® 1-Day (Verofilcon A; silicone hydrogel). Using a simple soaking method, the Biomedic lenses exhibited markedly higher loading capacities (up to ~ 40–45 mg per lens) and adsorption efficiencies (~ 50–60%) compared with Precision lenses (< 20 mg; <40%), attributable to the hydrophilic pHEMA/MAA network that enables hydrogen bonding and electrostatic interactions with β-lactam antibiotics. Scanning electron microscopy showed that the Biomedic lenses had more porosity than the Precision lenses, re-confirming the higher drug loading. FT-IR spectroscopy confirmed non-covalent drug incorporation and the drugs were adsorbed in molecular dispersion forms. Both drug-loaded lenses maintained high optical transparency (> 80% transmittance), indicating suitability for therapeutic wear. In vitro release studies revealed biphasic kinetics with an initial burst followed by sustained diffusion-controlled release, with Biomedic lenses showed more prolonged release than the Precision 1 lenses. Conclusively, the developed system, especially the dual-drug-loaded Biomedic lenses, could represent a promising localized drug-delivery strategy to enhance ocular residence time, reduce dosing frequency, and improve management of perforated bacterial keratitis.