Scholarlink

<p>Sepsis and septic shock are associated with profound pathophysiological changes that alter drug pharmacokinetics, complicating optimal medication dosing in critically ill patients. Inadequate understanding of these alterations may result in inappropriate drug exposure, potentially leading to treatment failure or toxicity. This study aimed to assess healthcare professionals’ knowledge, attitudes, and behaviors regarding pharmacokinetic-guided drug dosing in sepsis and septic shock. A cross-sectional survey study was conducted among physicians and clinical pharmacists in Türkiye between September and December 2025. A structured questionnaire was developed using a modified Delphi process and assessed knowledge, attitudes, behaviors, and clinical application through a dosing scenario. A total of 203 healthcare professionals participated. The mean knowledge score was 3.67 ± 1.70 out of 7, with only 31.5% demonstrating high knowledge levels. Notable gaps were identified in areas such as anticoagulant dosing and pharmacokinetic changes during continuous renal replacement therapy. Despite these gaps, participants reported positive attitudes toward individualized dosing (mean score: 4.25 ± 0.30) and generally favorable practices (mean score: 4.00 ± 0.64). Clinical pharmacists demonstrated significantly higher knowledge scores than physicians (<i>p</i> &lt; 0.001) and greater accuracy in the clinical scenario (94.1% vs. 72.8%, <i>p</i> = 0.008). Substantial knowledge gaps exist among healthcare professionals regarding pharmacokinetic-guided drug dosing in sepsis. The identified knowledge gaps may increase the risk of inappropriate dosing decisions, although actual prescribing behavior, drug exposure, and patient outcomes were not evaluated. Targeted educational interventions and strengthened multidisciplinary collaboration are essential to support safer and more effective medication use in the intensive care setting.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Knowledge gaps in pharmacokinetically guided drug dosing for sepsis among healthcare professionals in Türkiye

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月4日

查看全文
  • Muzeyyen Aksoy,
  • Enes Emir Ilerler,
  • Erdem Yalcinkaya,
  • Umut Sabri Kasapoglu,
  • Huseyin Arikan,
  • Sait Karakurt,
  • Mesut Sancar

摘要

Sepsis and septic shock are associated with profound pathophysiological changes that alter drug pharmacokinetics, complicating optimal medication dosing in critically ill patients. Inadequate understanding of these alterations may result in inappropriate drug exposure, potentially leading to treatment failure or toxicity. This study aimed to assess healthcare professionals’ knowledge, attitudes, and behaviors regarding pharmacokinetic-guided drug dosing in sepsis and septic shock. A cross-sectional survey study was conducted among physicians and clinical pharmacists in Türkiye between September and December 2025. A structured questionnaire was developed using a modified Delphi process and assessed knowledge, attitudes, behaviors, and clinical application through a dosing scenario. A total of 203 healthcare professionals participated. The mean knowledge score was 3.67 ± 1.70 out of 7, with only 31.5% demonstrating high knowledge levels. Notable gaps were identified in areas such as anticoagulant dosing and pharmacokinetic changes during continuous renal replacement therapy. Despite these gaps, participants reported positive attitudes toward individualized dosing (mean score: 4.25 ± 0.30) and generally favorable practices (mean score: 4.00 ± 0.64). Clinical pharmacists demonstrated significantly higher knowledge scores than physicians (p < 0.001) and greater accuracy in the clinical scenario (94.1% vs. 72.8%, p = 0.008). Substantial knowledge gaps exist among healthcare professionals regarding pharmacokinetic-guided drug dosing in sepsis. The identified knowledge gaps may increase the risk of inappropriate dosing decisions, although actual prescribing behavior, drug exposure, and patient outcomes were not evaluated. Targeted educational interventions and strengthened multidisciplinary collaboration are essential to support safer and more effective medication use in the intensive care setting.