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<p>The Gut microbiota is crucial for regulating immune responses in autoimmune neuropathies like Guillain–Barré syndrome (GBS). Yet, its influence on disease course and recovery remains unclear. This study examined gut microbiota dysbiosis in 57 GBS patients and 57 age- and gender-matched healthy controls, following 32 patients for six months to identify microbial signatures associated with disease onset and clinical progression. Gut microbiota profile was obtained through 16S rRNA sequencing (V4-region) and processed using Qiime2-Dada2. Alpha/beta diversity matrices and linear discriminant analysis were applied. Acute-GBS showed significantly altered microbial composition compared to controls, with elevated <i>Enterococcus</i>, <i>Streptococcus</i>, <i>Bacteroides</i>, <i>Ruminococcues-gnavus-group</i>,<i> Lachnoclostridium</i>, taxa, along with reduced <i>Prevotella</i>, <i>Alloprevotella</i>, <i>Megasphaera</i>, <i>Dialister</i>, and <i>Agathobacter</i>. Severe GBS correlated with lower <i>Prevotella</i>, <i>Agathobacter</i>, <i>Subdoligranulum</i>, <i>Dialister</i>, and elevated <i>Enterococcus</i> abundance. At six-months, <i>Streptococcus</i>, <i>Agathobacter</i>, and <i>Eubacterium hallii</i> trended toward normalization, while <i>Enterococcus</i>, <i>Clostridium sensu stricto</i>-<i>1</i>, <i>Romboutsia</i>, <i>Dialistes</i>, <i>Alloprevotella</i>, and <i>Prevotella</i> remained persistently altered. Patients with good 6-months outcomes exhibited reduced <i>Bacteroides</i>, <i>Weissella</i>, <i>UCG-002</i> and increased <i>Lactobacillus</i>, <i>Ruminococcus gauvreauii</i>, <i>Blautia</i>, <i>Collinsella</i>, and <i>Megasphaera</i>. These findings identify distinct gut microbial signatures associated with GBS onset and clinical course, highlighting their potential as exploratory microbiome-associated biomarkers linked with prognosis that require further validation.</p>

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Distinct gut microbial signatures associated with disease onset and clinical course in Guillain–Barre syndrome

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Israt Jahan,
  • Asaduzzaman Asad,
  • Md. Abu Jaher Nayeem,
  • Rasel Ahmed,
  • Ruma Begum,
  • Mohammad Jubair,
  • Quazi Deen Mohammad,
  • Sonja E. Leonhard,
  • Bart C. Jacobs,
  • Hubert P. Endtz,
  • Zhahirul Islam

摘要

The Gut microbiota is crucial for regulating immune responses in autoimmune neuropathies like Guillain–Barré syndrome (GBS). Yet, its influence on disease course and recovery remains unclear. This study examined gut microbiota dysbiosis in 57 GBS patients and 57 age- and gender-matched healthy controls, following 32 patients for six months to identify microbial signatures associated with disease onset and clinical progression. Gut microbiota profile was obtained through 16S rRNA sequencing (V4-region) and processed using Qiime2-Dada2. Alpha/beta diversity matrices and linear discriminant analysis were applied. Acute-GBS showed significantly altered microbial composition compared to controls, with elevated Enterococcus, Streptococcus, Bacteroides, Ruminococcues-gnavus-group, Lachnoclostridium, taxa, along with reduced Prevotella, Alloprevotella, Megasphaera, Dialister, and Agathobacter. Severe GBS correlated with lower Prevotella, Agathobacter, Subdoligranulum, Dialister, and elevated Enterococcus abundance. At six-months, Streptococcus, Agathobacter, and Eubacterium hallii trended toward normalization, while Enterococcus, Clostridium sensu stricto-1, Romboutsia, Dialistes, Alloprevotella, and Prevotella remained persistently altered. Patients with good 6-months outcomes exhibited reduced Bacteroides, Weissella, UCG-002 and increased Lactobacillus, Ruminococcus gauvreauii, Blautia, Collinsella, and Megasphaera. These findings identify distinct gut microbial signatures associated with GBS onset and clinical course, highlighting their potential as exploratory microbiome-associated biomarkers linked with prognosis that require further validation.