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<p>Breast cancer is the most common form of cancer in females, the treatment or prophylaxis of which often requires a single or double mastectomy. Following mastectomy, a minority of women opt to undergo reconstructive surgery, which can be achieved using implants, flap-based procedures or autologous fat grafting. Whilst breast reconstruction has many net benefits, each of these techniques comes with a host of problems, including the need to undergo future surgeries and long-term sequelae. Recent advancements in the fields of 3D-printing and regenerative medicine have opened the door to a novel approach; 3D-printed bio-based scaffold implants designed to support autologous tissue ingrowth. In this study, we present a new 3D printed porous scaffold (3DPPS) made of a gelatin and alginate blend and assess a range of the implant’s functional properties in vitro and in vivo, including mechanical properties, cytotoxicity, cell survival and proliferation, vascularisation and implant resorption. We demonstrate that, in vitro, our 3DPPS is not cytotoxic towards human cells, supports cell colonisation, extracellular matrix neosynthesis, blood vessel infiltration and angiogenesis in grafted human adipose tissue. In vivo, the 3DPPS has a favourable biocompatibility profile in rodents. Overall, our results represent a significant step forward in the search for a regenerative approach to breast reconstruction.</p>

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Novel natural hydrogel-based, 3D-printed biomimetic prosthesis for breast volume reconstruction

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月31日

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  • Audrey Cherblanc,
  • Baptiste Godet,
  • Marilou Gleizes,
  • Luciano Vidal,
  • Christophe A. Marquette,
  • Amélie Thepot,
  • Morgan Dos Santos,
  • Caroline Durand

摘要

Breast cancer is the most common form of cancer in females, the treatment or prophylaxis of which often requires a single or double mastectomy. Following mastectomy, a minority of women opt to undergo reconstructive surgery, which can be achieved using implants, flap-based procedures or autologous fat grafting. Whilst breast reconstruction has many net benefits, each of these techniques comes with a host of problems, including the need to undergo future surgeries and long-term sequelae. Recent advancements in the fields of 3D-printing and regenerative medicine have opened the door to a novel approach; 3D-printed bio-based scaffold implants designed to support autologous tissue ingrowth. In this study, we present a new 3D printed porous scaffold (3DPPS) made of a gelatin and alginate blend and assess a range of the implant’s functional properties in vitro and in vivo, including mechanical properties, cytotoxicity, cell survival and proliferation, vascularisation and implant resorption. We demonstrate that, in vitro, our 3DPPS is not cytotoxic towards human cells, supports cell colonisation, extracellular matrix neosynthesis, blood vessel infiltration and angiogenesis in grafted human adipose tissue. In vivo, the 3DPPS has a favourable biocompatibility profile in rodents. Overall, our results represent a significant step forward in the search for a regenerative approach to breast reconstruction.