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<p>Noninvasive and real-time methods for tracking the neural dynamics of memory processing remain limited. Here, we tested whether fluctuations in pupil size were associated with trial-to-trial variations in memory performance and how their temporal and discriminative properties compared with intracranial EEG (iEEG) signals. Seven epilepsy patients implanted with electrodes for seizure monitoring performed a free-recall verbal memory task while pupillometry and iEEG signals were recorded simultaneously. Trials were categorized as good or poor based on immediate recall performance, revealing pupil responses that differentiated the trial type &#xa0;600 ms before word presentation and &#xa0;200 ms before recall vocalization. These effects showed broadly comparable timing, discriminative strength, and classification performance to simplified iEEG power-in-band features obtained from multiple cortical regions and frequency bands. Our results suggest using pupil dynamics as an accessible biomarker of immediate memory performance in research, clinical and other applications.</p>

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Pupil size as an early and accessible biomarker of memory performance: a comparative intracranial EEG study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月5日

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  • Nastaran Hamedi,
  • Luis F. Sarmiento,
  • Michal Lech,
  • Cagdas Topcu,
  • Victoria S. Marks,
  • Boney Joseph,
  • Jaromir Dolezal,
  • Andrzej Czyzewski,
  • Gregory A. Worrell,
  • Michal T. Kucewicz

摘要

Noninvasive and real-time methods for tracking the neural dynamics of memory processing remain limited. Here, we tested whether fluctuations in pupil size were associated with trial-to-trial variations in memory performance and how their temporal and discriminative properties compared with intracranial EEG (iEEG) signals. Seven epilepsy patients implanted with electrodes for seizure monitoring performed a free-recall verbal memory task while pupillometry and iEEG signals were recorded simultaneously. Trials were categorized as good or poor based on immediate recall performance, revealing pupil responses that differentiated the trial type  600 ms before word presentation and  200 ms before recall vocalization. These effects showed broadly comparable timing, discriminative strength, and classification performance to simplified iEEG power-in-band features obtained from multiple cortical regions and frequency bands. Our results suggest using pupil dynamics as an accessible biomarker of immediate memory performance in research, clinical and other applications.