Scholarlink

<p>Gastrointestinal and neuropsychiatric disorders frequently co-occur, but their shared plasma-proteomic associations across disease stages remain unclear. We analyzed 2,920 plasma proteins in 52,953 UK Biobank participants across seven gastrointestinal and nine neuropsychiatric outcomes during a median follow-up of 13.3 years. Proteome-wide Cox analyses identified shared proteins associated with outcomes in both systems. In a strictly nested analysis of 45,811 participants without a study endpoint at baseline, training-only screening identified 198 proteins for CoMorbNet feature prioritization. The cross-system comorbidity model achieved an AUC of 0.717 in a nested held-out validation analysis. Compared with the low-score tertile, the high-score tertile was associated with higher hazards (HRs) across all five disease transitions (HRs, 1.54–2.15; all <i>P</i> &lt; 0.001). Shared proteins were enriched in immune-related pathways. These findings identify stage-specific proteomic patterns associated with gastrointestinal-neuropsychiatric comorbidity, but external validation is required before clinical use.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Proteomic signatures reveal stage-specific progression across gastrointestinal–neuropsychiatric comorbidity: a deep learning and multi-state trajectory analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月1日

查看全文
  • Xiaohua Ye,
  • Zhenhe Jin,
  • Tianyu Zhou,
  • Zhijian Zhao,
  • Chunmin Lou,
  • Chengwei Xu,
  • Kexin Ye,
  • Yandong Li,
  • Yufan Wang,
  • Chaohui Yu,
  • Zhe Shen

摘要

Gastrointestinal and neuropsychiatric disorders frequently co-occur, but their shared plasma-proteomic associations across disease stages remain unclear. We analyzed 2,920 plasma proteins in 52,953 UK Biobank participants across seven gastrointestinal and nine neuropsychiatric outcomes during a median follow-up of 13.3 years. Proteome-wide Cox analyses identified shared proteins associated with outcomes in both systems. In a strictly nested analysis of 45,811 participants without a study endpoint at baseline, training-only screening identified 198 proteins for CoMorbNet feature prioritization. The cross-system comorbidity model achieved an AUC of 0.717 in a nested held-out validation analysis. Compared with the low-score tertile, the high-score tertile was associated with higher hazards (HRs) across all five disease transitions (HRs, 1.54–2.15; all P < 0.001). Shared proteins were enriched in immune-related pathways. These findings identify stage-specific proteomic patterns associated with gastrointestinal-neuropsychiatric comorbidity, but external validation is required before clinical use.