Scholarlink

<p>Curcuminoid effects on aging dog proteomes remain underexplored. Plasma shotgun proteomics revealed that 135-day curcuminoid supplementation significantly altered 2,224 proteins (p &lt; 0.05), with 1,154 differentially expressed (fold-change &gt; 2): 582 upregulated and 572 downregulated versus baseline. Curcuminoids enhanced proteins involved in metabolism, autophagy, and repair while suppressing inflammation, calcium signaling, and coagulation factors. Notably, curcuminoids modulated JAK-STAT signaling by upregulating negative regulators PIAS2 and SOCS2, reducing pro-inflammatory complement and coagulation factors, indicating diminished inflammaging. mTOR pathway modulation featured upregulation of negative regulators including stress-inducible geroprotective SESN2, plus GRB10, SGK1, ULK1, and PRKCA. Curcuminoids rebalanced calcium signaling networks via ITPR1, CALML4, CACNA1H, STIM2, and MYLK4 regulation—essential for muscle function and neuronal health—reducing age-related dysregulation. Proteomic shifts corresponded to improved oxidative stress markers: lower plasma malondialdehyde and restored glutathione redox status. Curcuminoids enhance metabolic flexibility, proteostasis, and immune resilience, emphasizing their geroprotective potential with translational relevance to humans.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Differential proteome profiling reveals curcuminoid-induced changes in metabolic and physiological pathways in aging dogs

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月28日

查看全文
  • Sataporn Phochantachinda,
  • Duangthip Chatchaisak,
  • Walasinee Sakcamduang,
  • Anchana Chansawhang,
  • Shutipen Buranasinsup,
  • Namphung Suemanotham,
  • Boonrat Chantong

摘要

Curcuminoid effects on aging dog proteomes remain underexplored. Plasma shotgun proteomics revealed that 135-day curcuminoid supplementation significantly altered 2,224 proteins (p < 0.05), with 1,154 differentially expressed (fold-change > 2): 582 upregulated and 572 downregulated versus baseline. Curcuminoids enhanced proteins involved in metabolism, autophagy, and repair while suppressing inflammation, calcium signaling, and coagulation factors. Notably, curcuminoids modulated JAK-STAT signaling by upregulating negative regulators PIAS2 and SOCS2, reducing pro-inflammatory complement and coagulation factors, indicating diminished inflammaging. mTOR pathway modulation featured upregulation of negative regulators including stress-inducible geroprotective SESN2, plus GRB10, SGK1, ULK1, and PRKCA. Curcuminoids rebalanced calcium signaling networks via ITPR1, CALML4, CACNA1H, STIM2, and MYLK4 regulation—essential for muscle function and neuronal health—reducing age-related dysregulation. Proteomic shifts corresponded to improved oxidative stress markers: lower plasma malondialdehyde and restored glutathione redox status. Curcuminoids enhance metabolic flexibility, proteostasis, and immune resilience, emphasizing their geroprotective potential with translational relevance to humans.