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<p>Physical activity (PA) is linked to reduced cardiovascular risk. This study investigated whether changes in PA, or lack thereof, after stroke influence long-term cardiovascular risk. The study included 498 first-ever ischemic stroke patients, with PA assessed pre-stroke and 6 months post-stroke via questionnaire. The primary outcome was a composite of new cardiovascular events or death, determined through register-based follow-up. Participants were categorized into PA change groups: consistently above the lowest quartile (reference), decreasing to the lowest quartile, increasing from the lowest quartile, and consistently in the lowest quartile. Cox proportional-hazards models were adjusted for demographics, clinical data, socioeconomic factors, quality-of-life measures, and functional status. The median age was 68 years (interquartile range 58–76), with 35% female. Median follow-up was 6.8 years (interquartile range 5.7–7.6), during which 156 events occurred. Adjusted hazard ratios for cardiovascular events or death were 1.71 (95% CI 0.96–3.06) for decreased PA, 1.75 (95% CI 0.99–3.10) for increased PA, and 2.56 (95% CI 1.37–4.78) for consistently low PA, compared to the reference group. Persistently low PA after stroke was associated with the highest risk of new events, even after adjusting for functional status and stroke severity.</p>

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Change in physical activity after ischemic stroke and risk of new vascular event or death: registry-based long-term follow-up

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月4日

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  • Andreas Gammelgaard Damsbo,
  • Rolf Ankerlund Blauenfeldt,
  • Søren Paaske Johnsen,
  • Grethe Andersen,
  • Janne Kaergaard Mortensen

摘要

Physical activity (PA) is linked to reduced cardiovascular risk. This study investigated whether changes in PA, or lack thereof, after stroke influence long-term cardiovascular risk. The study included 498 first-ever ischemic stroke patients, with PA assessed pre-stroke and 6 months post-stroke via questionnaire. The primary outcome was a composite of new cardiovascular events or death, determined through register-based follow-up. Participants were categorized into PA change groups: consistently above the lowest quartile (reference), decreasing to the lowest quartile, increasing from the lowest quartile, and consistently in the lowest quartile. Cox proportional-hazards models were adjusted for demographics, clinical data, socioeconomic factors, quality-of-life measures, and functional status. The median age was 68 years (interquartile range 58–76), with 35% female. Median follow-up was 6.8 years (interquartile range 5.7–7.6), during which 156 events occurred. Adjusted hazard ratios for cardiovascular events or death were 1.71 (95% CI 0.96–3.06) for decreased PA, 1.75 (95% CI 0.99–3.10) for increased PA, and 2.56 (95% CI 1.37–4.78) for consistently low PA, compared to the reference group. Persistently low PA after stroke was associated with the highest risk of new events, even after adjusting for functional status and stroke severity.