Scholarlink

<p>Assessment of left ventricular (LV) dyssynchrony is important for diagnosing and guiding therapy in heart failure. Displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) quantifies myocardial dyssynchrony but lacks robust reference values. Forty healthy Caucasian volunteers (18–60 years) with no history of cardiac diseases underwent CMR at 1.5T MRI scanner using 2D spiral cine DENSE research sequence. Three short-axis slices (basal, mid-ventricular, apical) were acquired from the LV. Phase images were processed with open-source DENSEanalysis software to measure circumferential (E<sub>cc</sub>) and radial (E<sub>rr</sub>) strains, from which circumferential uniformity estimate (CURE) and radial uniformity estimate (RURE) were computed. Participants were categorized by sex and age into groups (18–30, 31–41, and 42–60 years). DENSE-derived strain values were also compared to those obtained using MRI feature tracking (FT). Males and females differed in average E<sub>cc</sub> (− 18 ± 4 vs. − 19 ± 5%, <i>p</i> = 0.01) and E<sub>rr</sub> (44 ± 20 vs. 36 ± 22%, <i>p</i> = 0.001), with no differences due to age. The apical segment of RURE was higher in males (<i>p</i> = 0.04), and age did not affect RURE. CURE showed no sex‑ or age‑related variation. The lower limit of normal was 0.80 for CURE and 0.64 for RURE. When FT was compared to DENSE, mean E<sub>cc</sub> was similar (− 20% vs. − 19%), though patient-level agreement was moderate (Intra class correlation (ICC) = 0.588, <i>p</i> = 0.013); FT showed lower E<sub>rr</sub> (mean 34% vs. 42%; ICC 0.304, <i>p</i> = 0.062). CURE demonstrated stable values across age and sex in healthy volunteers, supporting its use as a robust marker of LV dyssynchrony with a normal threshold of ≥ 0.80. In contrast, RURE showed greater variability, although a lower reference limit of ≥ 0.64 was established.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Normal CURE and RURE values for displacement encoding with stimulated echoes (DENSE) at 1.5 Tesla MRI

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月27日

查看全文
  • Minna Husso,
  • Mimmi Liukkonen,
  • Elias Ylä-Herttuala,
  • Xiaoying Cai,
  • Suvi Hartikainen,
  • Marja Hedman,
  • Martin Ugander,
  • Saara Sillanmäki

摘要

Assessment of left ventricular (LV) dyssynchrony is important for diagnosing and guiding therapy in heart failure. Displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) quantifies myocardial dyssynchrony but lacks robust reference values. Forty healthy Caucasian volunteers (18–60 years) with no history of cardiac diseases underwent CMR at 1.5T MRI scanner using 2D spiral cine DENSE research sequence. Three short-axis slices (basal, mid-ventricular, apical) were acquired from the LV. Phase images were processed with open-source DENSEanalysis software to measure circumferential (Ecc) and radial (Err) strains, from which circumferential uniformity estimate (CURE) and radial uniformity estimate (RURE) were computed. Participants were categorized by sex and age into groups (18–30, 31–41, and 42–60 years). DENSE-derived strain values were also compared to those obtained using MRI feature tracking (FT). Males and females differed in average Ecc (− 18 ± 4 vs. − 19 ± 5%, p = 0.01) and Err (44 ± 20 vs. 36 ± 22%, p = 0.001), with no differences due to age. The apical segment of RURE was higher in males (p = 0.04), and age did not affect RURE. CURE showed no sex‑ or age‑related variation. The lower limit of normal was 0.80 for CURE and 0.64 for RURE. When FT was compared to DENSE, mean Ecc was similar (− 20% vs. − 19%), though patient-level agreement was moderate (Intra class correlation (ICC) = 0.588, p = 0.013); FT showed lower Err (mean 34% vs. 42%; ICC 0.304, p = 0.062). CURE demonstrated stable values across age and sex in healthy volunteers, supporting its use as a robust marker of LV dyssynchrony with a normal threshold of ≥ 0.80. In contrast, RURE showed greater variability, although a lower reference limit of ≥ 0.64 was established.