Scholarlink

<p>A wide range of diagnostic information in medicine is currently obtained using radioactive tracers. While central to nuclear medicine, these methods face inherent limitations: radiation dose restricts repeat examinations, short tracer half-lives and complex logistics limit accessibility and increase costs, and relatively low spatial resolution often necessitates complementary CT or MRI. Here we present a first proof-of-concept demonstration of an alternative imaging modality based on x-ray fluorescence (XRF) computational ghost imaging (CGI) at the human-organ scale. Using a thyroid phantom filled with iodine solution as a model system, we show that structured illuminations combined with fluorescence detection reconstruct the iodine distribution with high fidelity. This approach avoids the use of radioactive tracers while preserving key aspects of the image structure and contrast. We report a spatial resolution of ~ 4.5&#xa0;mm in the current implementation, with potential for further improvement through system optimization. Beyond this demonstration, XRF-CGI establishes a generalizable framework for tracer imaging without radionuclides, opening a route toward safer, repeatable, and more accessible diagnostics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Human-organ-scale x-ray fluorescence ghost imaging for radioisotope-free diagnostics

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月17日

查看全文
  • Eli Levinson,
  • Rachel H. Shukrun,
  • Nicola Viganò,
  • Sharon Shwartz

摘要

A wide range of diagnostic information in medicine is currently obtained using radioactive tracers. While central to nuclear medicine, these methods face inherent limitations: radiation dose restricts repeat examinations, short tracer half-lives and complex logistics limit accessibility and increase costs, and relatively low spatial resolution often necessitates complementary CT or MRI. Here we present a first proof-of-concept demonstration of an alternative imaging modality based on x-ray fluorescence (XRF) computational ghost imaging (CGI) at the human-organ scale. Using a thyroid phantom filled with iodine solution as a model system, we show that structured illuminations combined with fluorescence detection reconstruct the iodine distribution with high fidelity. This approach avoids the use of radioactive tracers while preserving key aspects of the image structure and contrast. We report a spatial resolution of ~ 4.5 mm in the current implementation, with potential for further improvement through system optimization. Beyond this demonstration, XRF-CGI establishes a generalizable framework for tracer imaging without radionuclides, opening a route toward safer, repeatable, and more accessible diagnostics.