<p>Global health disparities remain a central concern in international public health. Sub-Saharan Africa, as defined by the United Nations M49 classification, has long experienced a disproportionate burden of communicable diseases, maternal and neonatal mortality, environmental health risks, and health system shortages. This analysis provides an up-to-date comparison of health inequalities in Sub-Saharan Africa to inform evidence-based global health policy, resource distribution, and collaborative international action. Using data from the World Health Organization (WHO) Global Health Observatory, this study conducted a comprehensive comparative analysis of health status indicators, risk factors, service coverage, and health system capacity between Sub-Saharan Africa and all other countries. The findings reveal striking and statistically significant disparities across nearly all indicators examined. Sub-Saharan Africa exhibited substantially higher incidence of tuberculosis and malaria, markedly elevated maternal and neonatal mortality, greater mortality attributable to unsafe water, sanitation and hygiene (WASH), air pollution, and violence, alongside profound shortages in health workforce density and service coverage. These results underscore the persistence of systemic global health inequities and highlight the urgent need for sustained investment in primary health care, health workforce development, environmental infrastructure, and equitable global partnerships to achieve Universal Health Coverage and the Sustainable Development Goals.</p>