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<p>Mosquito-borne diseases remain an important global public health concern, and increasing insecticide resistance has strengthened interest in complementary personal protection tools. This study evaluated the short-term dermal tolerability and laboratory repellency of MosShield, a ready-to-use topical spray formulated with 6% w/w <i>Litsea cubeba</i> essential oil. Non-confidential formulation quality-control parameters, including appearance, homogeneity, pH, density, and apparent viscosity, were recorded to support formulation consistency before testing. Short-term dermal tolerability was assessed using a human skin-patch test in 48 healthy volunteers, with no visible skin reactions observed up to 96&#xa0;h after application. Repellency assays were conducted following the World Health Organization arm-in-cage protocol against three medically important mosquito species: <i>Aedes aegypti</i>,<i> Anopheles dirus</i>, and <i>Culex quinquefasciatus</i>. The formulation showed species-dependent repellency, achieving median complete protection times of 225&#xa0;min against <i>Cx. quinquefasciatus</i> and 120&#xa0;min against both <i>Ae. aegypti</i> and <i>An. dirus.</i> These findings provide product-relevant laboratory evidence supporting further evaluation of the 6% <i>L. cubeba</i> essential oil spray as a plant-based topical mosquito repellent under semi-field and field conditions.</p>

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Topical mosquito repellency of a Litsea cubeba essential oil spray against Aedes aegypti, Anopheles dirus, and Culex quinquefasciatus

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月14日

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  • Nataya Sutthanont,
  • Jiraporn Leanpolchareanchai,
  • Patchara Sriwichai,
  • Jiraporn Ruangsittichai,
  • Theerawit Phanpoowong,
  • Suchada Sumruayphol,
  • Thipruethai Phanitchat,
  • Toshio Sakai,
  • Yuki Eshita,
  • Raweewan Srisawat

摘要

Mosquito-borne diseases remain an important global public health concern, and increasing insecticide resistance has strengthened interest in complementary personal protection tools. This study evaluated the short-term dermal tolerability and laboratory repellency of MosShield, a ready-to-use topical spray formulated with 6% w/w Litsea cubeba essential oil. Non-confidential formulation quality-control parameters, including appearance, homogeneity, pH, density, and apparent viscosity, were recorded to support formulation consistency before testing. Short-term dermal tolerability was assessed using a human skin-patch test in 48 healthy volunteers, with no visible skin reactions observed up to 96 h after application. Repellency assays were conducted following the World Health Organization arm-in-cage protocol against three medically important mosquito species: Aedes aegypti, Anopheles dirus, and Culex quinquefasciatus. The formulation showed species-dependent repellency, achieving median complete protection times of 225 min against Cx. quinquefasciatus and 120 min against both Ae. aegypti and An. dirus. These findings provide product-relevant laboratory evidence supporting further evaluation of the 6% L. cubeba essential oil spray as a plant-based topical mosquito repellent under semi-field and field conditions.