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<p>Early-onset neonatal sepsis (EONS) remains a challenging diagnosis in clinical practice, with limited available paraclinical data. This study aims to analyze the utility of two cytokines determined from the umbilical cord blood (UCB) of newborns and from maternal blood, IL-6 and IL-8, for the early and accurate diagnosis of EONS. The study population was divided into a study group (50 patients with confirmed EONS) and control group (50 patients with sepsis risk factors, without a confirmed infection). UCB IL levels were significantly higher in the study group for both IL-6 (44.28 ± 23.10&#xa0;pg/mL versus 5.54 ± 4.14&#xa0;pg/mL, <i>p</i> &lt; 0.01) and IL-8 (15.48 ± 7.56 versus 5.31 ± 2.58&#xa0;pg/mL, <i>p</i> &lt; 0.01). For the distinction between confirmed EONS and healthy controls with risk factors, cut-off levels of &gt; 16.34&#xa0;pg/mL were identified for IL-6 and of &gt; 7.59&#xa0;pg/mL for IL-8, respectively. UCB IL-6 and IL-8 levels correlated with neonatal leukocyte, neutrophil, lymphocyte levels, as well as with the leukocyte index. Maternal IL-6 and IL-8 levels did not differ significantly between the two study groups and did not corelate with their UCB homologues. Maternal levels of IL-6 and IL-8 could not predict EONS, in contradistinction to UCB IL-6 and IL-8 levels, that seem to be useful in the early stratification and diagnosis of EONS among term neonates. Future research, expanded on wider neonatal cohorts is warranted to deliver more information regarding the utility of UCB ILs into daily clinical practice, for precocious identification of populations at risk of developing EONS.</p>

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Role of umbilical cord and maternal blood levels of IL-6 and IL-8 in the diagnosis and prediction of early-onset neonatal sepsis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Maria-Andreea Răcean,
  • Maria Oana Săsăran,
  • Adina Huțanu,
  • Manuela Cucerea,
  • Laura Mihaela Suciu,
  • Cristina Oana Mărginean

摘要

Early-onset neonatal sepsis (EONS) remains a challenging diagnosis in clinical practice, with limited available paraclinical data. This study aims to analyze the utility of two cytokines determined from the umbilical cord blood (UCB) of newborns and from maternal blood, IL-6 and IL-8, for the early and accurate diagnosis of EONS. The study population was divided into a study group (50 patients with confirmed EONS) and control group (50 patients with sepsis risk factors, without a confirmed infection). UCB IL levels were significantly higher in the study group for both IL-6 (44.28 ± 23.10 pg/mL versus 5.54 ± 4.14 pg/mL, p < 0.01) and IL-8 (15.48 ± 7.56 versus 5.31 ± 2.58 pg/mL, p < 0.01). For the distinction between confirmed EONS and healthy controls with risk factors, cut-off levels of > 16.34 pg/mL were identified for IL-6 and of > 7.59 pg/mL for IL-8, respectively. UCB IL-6 and IL-8 levels correlated with neonatal leukocyte, neutrophil, lymphocyte levels, as well as with the leukocyte index. Maternal IL-6 and IL-8 levels did not differ significantly between the two study groups and did not corelate with their UCB homologues. Maternal levels of IL-6 and IL-8 could not predict EONS, in contradistinction to UCB IL-6 and IL-8 levels, that seem to be useful in the early stratification and diagnosis of EONS among term neonates. Future research, expanded on wider neonatal cohorts is warranted to deliver more information regarding the utility of UCB ILs into daily clinical practice, for precocious identification of populations at risk of developing EONS.