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<p>Dupuytren’s contracture (DC) is a fibroproliferative disorder of the palmar fascia with substantial variation in prevalence across populations. However, epidemiological data from Asian countries remain limited, and little is known about upper-limb–specific quality of life or dietary correlates associated with DC. This cross-sectional study investigated the prevalence of DC in a community-dwelling Japanese population, assessed its impact on upper-limb function, and examined demographic, medical, lifestyle, and dietary correlates. DC diagnosis and severity were evaluated by hand surgeons using the original 5-grade clinical staging system proposed by Meyerding in 1936, a historical but practical method for epidemiological surveys that categorizes disease severity based on the number of affected digits and degree of flexion deformity. Demographic and lifestyle data were collected using standardized questionnaires, biochemical parameters were measured from fasting blood samples, upper-limb disability was assessed using the Quick Disabilities of the Arm, Shoulder and Hand (qDASH), and nutrient intake during the preceding month was estimated using the validated Brief Diet History Questionnaire (BDHQ). Among 1,304 participants, DC was identified in 100 (7.7%), with most cases classified as grade 0 (palpable nodules without digital flexion contracture). In univariate analyses, older age, male sex, smoking, diabetes mellitus, manual labor, and several nutrient intakes—including alcohol, protein, carbohydrate, sodium, and omega-3 fatty acids—were associated with DC. Multivariate analyses showed that older age, male sex, and alcohol intake were positively associated with DC. An inverse association between total energy intake and DC was also observed. No measurable difference in qDASH scores was observed according to the presence or severity of DC in this screening cohort. These findings provide additional epidemiological data on DC in a community-dwelling Japanese population, in which most detected cases were mild and identified at an early stage. The BDHQ-based dietary analyses were secondary and exploratory. Although alcohol intake was positively associated with DC, the dietary findings, including the inverse association with total energy intake, should be regarded as hypothesis-generating and require confirmation in longitudinal studies.</p>

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Prevalence and related factors of Dupuytren’s contracture in a community-dwelling Japanese population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月7日

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  • Yuki Matsuyama,
  • Takashi Shimoe,
  • Hiroshi Hashizume,
  • Mito Hayashi,
  • Shoei Iwata,
  • Mayumi Fukasawa,
  • Shuhei Tsujimoto,
  • Kazunori Shinto,
  • Yusuke Kido,
  • Akimasa Murata,
  • Nobuyuki Miyai,
  • Hiroshi Yamada

摘要

Dupuytren’s contracture (DC) is a fibroproliferative disorder of the palmar fascia with substantial variation in prevalence across populations. However, epidemiological data from Asian countries remain limited, and little is known about upper-limb–specific quality of life or dietary correlates associated with DC. This cross-sectional study investigated the prevalence of DC in a community-dwelling Japanese population, assessed its impact on upper-limb function, and examined demographic, medical, lifestyle, and dietary correlates. DC diagnosis and severity were evaluated by hand surgeons using the original 5-grade clinical staging system proposed by Meyerding in 1936, a historical but practical method for epidemiological surveys that categorizes disease severity based on the number of affected digits and degree of flexion deformity. Demographic and lifestyle data were collected using standardized questionnaires, biochemical parameters were measured from fasting blood samples, upper-limb disability was assessed using the Quick Disabilities of the Arm, Shoulder and Hand (qDASH), and nutrient intake during the preceding month was estimated using the validated Brief Diet History Questionnaire (BDHQ). Among 1,304 participants, DC was identified in 100 (7.7%), with most cases classified as grade 0 (palpable nodules without digital flexion contracture). In univariate analyses, older age, male sex, smoking, diabetes mellitus, manual labor, and several nutrient intakes—including alcohol, protein, carbohydrate, sodium, and omega-3 fatty acids—were associated with DC. Multivariate analyses showed that older age, male sex, and alcohol intake were positively associated with DC. An inverse association between total energy intake and DC was also observed. No measurable difference in qDASH scores was observed according to the presence or severity of DC in this screening cohort. These findings provide additional epidemiological data on DC in a community-dwelling Japanese population, in which most detected cases were mild and identified at an early stage. The BDHQ-based dietary analyses were secondary and exploratory. Although alcohol intake was positively associated with DC, the dietary findings, including the inverse association with total energy intake, should be regarded as hypothesis-generating and require confirmation in longitudinal studies.