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<p>Limited data are available on the antimicrobial susceptibility of environmental <i>Legionella pneumophila</i> strains in China. This study investigated the susceptibility of <i>Legionella pneumophila</i> strains isolated from shower water in public bathing facilities in Shandong Province, China, to six commonly used antimicrobial agents for treating Legionnaires’ disease, thereby providing regional data for establishing international ECOFF values. Reduced susceptibility strains were detected in all six antimicrobial agents. Erythromycin exhibited the highest rate of non-wild type strains (35 strains, MIC &gt; 0.5, MIC50 = 0.75&#xa0;mg/L, MIC90 = 12&#xa0;mg/L). Rifampin followed (32 strains, MIC &gt; 0.032, MIC50 = 0.047&#xa0;mg/L, MIC90 = 0.25&#xa0;mg/L). Levofloxacin (25 strains, MIC &gt; 0.25, MIC50 = 0.38&#xa0;mg/L, MIC90 = 1.5&#xa0;mg/L). Azithromycin (21 strains, MIC &gt; 0.25, MIC50 = 0.125&#xa0;mg/L, MIC90 = 2&#xa0;mg/L). Moxifloxacin (17 strains, MIC &gt; 1, MIC50 = 1&#xa0;mg/L, MIC90 = 6&#xa0;mg/L). Cefuroxime lacks a provisional ECOFF value; most strains had MIC = 16, MIC50 = 12&#xa0;mg/L. No significant MIC difference was found between serogroup 1 and other serogroups (<i>p</i> &gt; 0.05). Research indicates that <i>Legionella pneumophila</i> in China exhibits geographically specific reduced drug susceptibility. Fluoroquinolones are the first-line treatment for <i>Legionella</i> pneumonia.</p>

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Antimicrobial susceptibility profile of environmental Legionella pneumophila isolates from shower water in Shandong Province, China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月7日

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  • Yuanyuan Jiang,
  • Chuan Qin,
  • Bin Hu,
  • Lianlong Yu,
  • Xiao Zhang,
  • Yanxin Gao,
  • Qun Yuan

摘要

Limited data are available on the antimicrobial susceptibility of environmental Legionella pneumophila strains in China. This study investigated the susceptibility of Legionella pneumophila strains isolated from shower water in public bathing facilities in Shandong Province, China, to six commonly used antimicrobial agents for treating Legionnaires’ disease, thereby providing regional data for establishing international ECOFF values. Reduced susceptibility strains were detected in all six antimicrobial agents. Erythromycin exhibited the highest rate of non-wild type strains (35 strains, MIC > 0.5, MIC50 = 0.75 mg/L, MIC90 = 12 mg/L). Rifampin followed (32 strains, MIC > 0.032, MIC50 = 0.047 mg/L, MIC90 = 0.25 mg/L). Levofloxacin (25 strains, MIC > 0.25, MIC50 = 0.38 mg/L, MIC90 = 1.5 mg/L). Azithromycin (21 strains, MIC > 0.25, MIC50 = 0.125 mg/L, MIC90 = 2 mg/L). Moxifloxacin (17 strains, MIC > 1, MIC50 = 1 mg/L, MIC90 = 6 mg/L). Cefuroxime lacks a provisional ECOFF value; most strains had MIC = 16, MIC50 = 12 mg/L. No significant MIC difference was found between serogroup 1 and other serogroups (p > 0.05). Research indicates that Legionella pneumophila in China exhibits geographically specific reduced drug susceptibility. Fluoroquinolones are the first-line treatment for Legionella pneumonia.