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<p>This study investigates the bioactive compounds, antioxidant properties, and antibacterial activities of <i>Teucrium polium</i> L. <i>ssp. thymoïdes</i>, a medicinal plant from the Lamiaceae family. Using various extraction solvents (methanol, ethanol, and dichloromethane), the study identifies key phenolic compounds and flavonoids through Thin Layer Chromatography (TLC) and High-Performance Liquid Chromatography (HPLC). The extracts exhibit significant antioxidant activity, with methanol providing the highest total phenolic content (185.6 ± 5.2&#xa0;mg GAE/g) and the strongest DPPH radical scavenging effect (IC<sub>50</sub> = 45.3 ± 2.1&#xa0;µg/mL). Additionally, antibacterial assays reveal strong activity against <i>Staphylococcus aureus</i> (inhibition zone: 18.5 ± 0.8&#xa0;mm, MIC: 125&#xa0;µg/mL) and <i>Escherichia coli</i> (15.3 ± 0.6&#xa0;mm, MIC: 250&#xa0;µg/mL). DFT calculations were performed to analyze the electronic properties of the identified compounds. The HOMO-LUMO energy gaps and quantum chemical descriptors support their observed antioxidant and antibacterial activities. The findings validate the plant’s traditional use and suggest its potential application in pharmaceutical and healthcare industries as a natural antioxidant and antibacterial agent. Future studies should explore seasonal and geographical variations in bioactive composition and further investigate the mechanisms behind its therapeutic effects.</p>

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Phytochemical study, solvent extraction efficiency, and antioxidant and antibacterial activities of Moroccan Teucrium polium L. ssp. thymoïdes: a combined experimental and DFT study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月31日

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  • Mariama Riyad,
  • Fatima Ezzahra Maaghloud,
  • Achraf Abdou,
  • Mostafa Kabine,
  • Mohamed Dakir

摘要

This study investigates the bioactive compounds, antioxidant properties, and antibacterial activities of Teucrium polium L. ssp. thymoïdes, a medicinal plant from the Lamiaceae family. Using various extraction solvents (methanol, ethanol, and dichloromethane), the study identifies key phenolic compounds and flavonoids through Thin Layer Chromatography (TLC) and High-Performance Liquid Chromatography (HPLC). The extracts exhibit significant antioxidant activity, with methanol providing the highest total phenolic content (185.6 ± 5.2 mg GAE/g) and the strongest DPPH radical scavenging effect (IC50 = 45.3 ± 2.1 µg/mL). Additionally, antibacterial assays reveal strong activity against Staphylococcus aureus (inhibition zone: 18.5 ± 0.8 mm, MIC: 125 µg/mL) and Escherichia coli (15.3 ± 0.6 mm, MIC: 250 µg/mL). DFT calculations were performed to analyze the electronic properties of the identified compounds. The HOMO-LUMO energy gaps and quantum chemical descriptors support their observed antioxidant and antibacterial activities. The findings validate the plant’s traditional use and suggest its potential application in pharmaceutical and healthcare industries as a natural antioxidant and antibacterial agent. Future studies should explore seasonal and geographical variations in bioactive composition and further investigate the mechanisms behind its therapeutic effects.