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<p>Psoriasis has been proposed to be associated with non-alcoholic fatty liver disease (NAFLD) through shared inflammatory pathways; however, the NAFLD risk in young psoriasis patients remains unclear. This study aims to investigate the risk of NAFLD in young patients with psoriasis versus non-psoriatic inflammatory skin diseases. We utilized data from the TriNetX global collaborative network, including patients aged 18–30 years with psoriasis or non-psoriatic inflammatory skin diseases. Patients were categorized into the PSO cohort or the NON-PSO skin diseases cohort, with 1:1 propensity score matched. The primary outcome was incident NAFLD with cumulative incidence plotted using Kaplan-Meier estimator and risk assessed via Cox regression. 2,473 patients were included in each cohort. During a 5-year follow-up, the incidence of NAFLD was elevated in the PSO cohort compared to the NON-PSO skin diseases cohort (6.46 vs. 4.11%), and the risk was higher in the PSO cohort (Hazard ratio: 1.607; 95% Confidence interval: 1.252–2.063). The elevated risk persisted across subgroup and sensitivity analyses after adjusting for metabolic factors and washout periods as well as comparing psoriasis with other inflammatory skin diseases. In conclusion, young psoriasis patients were associated with an increased risk of NAFLD compared to non-psoriatic inflammatory skin disease counterparts.</p>

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Investigating the risk of non-alcoholic fatty liver disease in young patients with psoriasis versus non-psoriatic inflammatory skin diseases

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  • 发表日期：

    2026年7月6日

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  • Wei-Wei Liu,
  • Chun-Ying Wu,
  • Yi-Ju Chen

摘要

Psoriasis has been proposed to be associated with non-alcoholic fatty liver disease (NAFLD) through shared inflammatory pathways; however, the NAFLD risk in young psoriasis patients remains unclear. This study aims to investigate the risk of NAFLD in young patients with psoriasis versus non-psoriatic inflammatory skin diseases. We utilized data from the TriNetX global collaborative network, including patients aged 18–30 years with psoriasis or non-psoriatic inflammatory skin diseases. Patients were categorized into the PSO cohort or the NON-PSO skin diseases cohort, with 1:1 propensity score matched. The primary outcome was incident NAFLD with cumulative incidence plotted using Kaplan-Meier estimator and risk assessed via Cox regression. 2,473 patients were included in each cohort. During a 5-year follow-up, the incidence of NAFLD was elevated in the PSO cohort compared to the NON-PSO skin diseases cohort (6.46 vs. 4.11%), and the risk was higher in the PSO cohort (Hazard ratio: 1.607; 95% Confidence interval: 1.252–2.063). The elevated risk persisted across subgroup and sensitivity analyses after adjusting for metabolic factors and washout periods as well as comparing psoriasis with other inflammatory skin diseases. In conclusion, young psoriasis patients were associated with an increased risk of NAFLD compared to non-psoriatic inflammatory skin disease counterparts.