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<p>Prostate cancer (PC) is one of the most common malignant tumors among men worldwide. Although treatment methods for localized PC are relatively well-established, challenges remain due to difficulties in early diagnosis and issues with treatment resistance. This study combines genome-wide association study (GWAS) data with tissue-specific expression quantitative trait loci (eQTL) data through a transcriptome-wide association study (TWAS) to explore key genes associated with PC. The study also includes differential expression analysis and survival analysis to further verify these findings. A total of 46 candidate genes were identified, and survival analysis using the Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) dataset revealed that the upregulation of asparagine synthetase (ASNS) is associated with poor prognosis, while the downregulation of sulfatase modifying factor 2 (SUMF2) is linked to adverse prognosis. The results suggest that ASNS and SUMF2 play important roles in the progression of PC and may serve as candidate prognostic biomarkers associated with PC progression.</p>

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Exploring key genes and prognostic validation of prostate cancer through transcriptome-wide association study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月4日

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  • Jintao Li,
  • Tao Tao,
  • Yuandong Zhang,
  • Xiangfeng Kong,
  • Yangyang Zhang,
  • Shuang Chen,
  • Yudong Huang

摘要

Prostate cancer (PC) is one of the most common malignant tumors among men worldwide. Although treatment methods for localized PC are relatively well-established, challenges remain due to difficulties in early diagnosis and issues with treatment resistance. This study combines genome-wide association study (GWAS) data with tissue-specific expression quantitative trait loci (eQTL) data through a transcriptome-wide association study (TWAS) to explore key genes associated with PC. The study also includes differential expression analysis and survival analysis to further verify these findings. A total of 46 candidate genes were identified, and survival analysis using the Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) dataset revealed that the upregulation of asparagine synthetase (ASNS) is associated with poor prognosis, while the downregulation of sulfatase modifying factor 2 (SUMF2) is linked to adverse prognosis. The results suggest that ASNS and SUMF2 play important roles in the progression of PC and may serve as candidate prognostic biomarkers associated with PC progression.