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<p>Blood pressure and heart rate are closely linked to mortality rates among the elderly. This observational cohort study aims to explore the combined association of mean arterial pressure (MAP) and resting heart rate (RHR) with all-cause mortality in the study population. Within the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted from 2008 to 2018, we established a cohort of participants aged 65 and older as of the baseline year, 2008. Restricted cubic spline regression models were employed to examine the dose–response relationships between MAP, RHR and mortality. Subsequently, a cox regression model was applied, adjusting for demographic characteristics, comorbidities, MAP, and RHR. The Kaplan–Meier (K-M) analysis examines the variations in mortality rates across different groups. Finally, a subgroup analysis was performed to evaluate the robustness of the results. Over a follow-up period of 10,264 person-years, 8,143 deaths were recorded. The relationship between MAP and mortality is nonlinear, with the lowest mortality observed at 92&#xa0;mmHg. Similarly, the RHR demonstrates the lowest mortality rate at 73 beats per minute (BPM). The population was divided into four groups based on MAP and RHR for cox regression. In the subgroup where the MAP is ≤ 92&#xa0;mmHg and the RHR is &gt; 73 BPM, an increase in MAP and a decrease in RHR are associated with a reduction in the mortality rate. Conversely, when MAP is &gt; 92&#xa0;mmHg and RHR is &gt; 73 BPM , RHR exhibits a stronger correlation with mortality. Additionally, in cases where MAP is &gt; 92&#xa0;mmHg and RHR is ≤ 73 BPM, MAP shows a closer association with mortality. K-M analysis demonstrated that the mortality rate was lowest in the group with MAP &gt; 92&#xa0;mmHg and RHR ≤ 73 BPM, with this difference being statistically significant (P &lt; 0.001). Similar results were also found in additional subgroup analyses. The lowest mortality rate corresponds to maintaining MAP at 92&#xa0;mmHg and RHR at 73 BPM.</p>

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Association of mean arterial pressure and resting heart rate with mortality in older adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月2日

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  • Xiangxiu Yao,
  • Chuangxin Zhang

摘要

Blood pressure and heart rate are closely linked to mortality rates among the elderly. This observational cohort study aims to explore the combined association of mean arterial pressure (MAP) and resting heart rate (RHR) with all-cause mortality in the study population. Within the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted from 2008 to 2018, we established a cohort of participants aged 65 and older as of the baseline year, 2008. Restricted cubic spline regression models were employed to examine the dose–response relationships between MAP, RHR and mortality. Subsequently, a cox regression model was applied, adjusting for demographic characteristics, comorbidities, MAP, and RHR. The Kaplan–Meier (K-M) analysis examines the variations in mortality rates across different groups. Finally, a subgroup analysis was performed to evaluate the robustness of the results. Over a follow-up period of 10,264 person-years, 8,143 deaths were recorded. The relationship between MAP and mortality is nonlinear, with the lowest mortality observed at 92 mmHg. Similarly, the RHR demonstrates the lowest mortality rate at 73 beats per minute (BPM). The population was divided into four groups based on MAP and RHR for cox regression. In the subgroup where the MAP is ≤ 92 mmHg and the RHR is > 73 BPM, an increase in MAP and a decrease in RHR are associated with a reduction in the mortality rate. Conversely, when MAP is > 92 mmHg and RHR is > 73 BPM , RHR exhibits a stronger correlation with mortality. Additionally, in cases where MAP is > 92 mmHg and RHR is ≤ 73 BPM, MAP shows a closer association with mortality. K-M analysis demonstrated that the mortality rate was lowest in the group with MAP > 92 mmHg and RHR ≤ 73 BPM, with this difference being statistically significant (P < 0.001). Similar results were also found in additional subgroup analyses. The lowest mortality rate corresponds to maintaining MAP at 92 mmHg and RHR at 73 BPM.