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<p>Despite substantial evidence confirming that intravenous-to-oral switch (IVOS) of antibiotics is non-inferior to intravenous administration in terms of efficacy and safety for various infections, intravenous antibiotics remain widely used in China, with patient preferences potentially influencing treatment decisions. This study aims to explore the willingness of Chinese residents to accept IVOS therapy and identify the associated factors using the Health Belief Model (HBM). A cross-sectional survey was conducted in Guangxi Province, China, from October to November 2025. A self-designed structured questionnaire was used to collect information on participants’ sociodemographic characteristics, antibiotic knowledge, and health beliefs. Structural equation modelling (SEM) was employed to analyze the factors influencing residents’ intention to accept IVOS therapy. A total of 400 participants were included in the study. Overall, residents’ knowledge of antibiotics was moderate, with an average correct response rate of 60% across 10 questions. Perceived benefits (β = 0.59, <i>p</i> &lt; 0.001) and self-efficacy (β = 0.27, <i>p</i> &lt; 0.001) were positively associated with the intention to accept IVOS therapy in this cross-sectional study. The HBM variables explained 56.4% of the variance in behavioral intention.</p>

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Factors influencing acceptance of intravenous-to-oral switch (IVOS) of antibiotics among residents in China: a cross-sectional study based on the health belief model (HBM)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月3日

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  • Yinqiu Deng,
  • Na Wei,
  • Qiuyan Chen,
  • Hongliang Zhang,
  • Fuli Qin,
  • Yi Chen,
  • Xiaomei Li,
  • Xian Chen,
  • Jun Luo,
  • Kunxuan Wei

摘要

Despite substantial evidence confirming that intravenous-to-oral switch (IVOS) of antibiotics is non-inferior to intravenous administration in terms of efficacy and safety for various infections, intravenous antibiotics remain widely used in China, with patient preferences potentially influencing treatment decisions. This study aims to explore the willingness of Chinese residents to accept IVOS therapy and identify the associated factors using the Health Belief Model (HBM). A cross-sectional survey was conducted in Guangxi Province, China, from October to November 2025. A self-designed structured questionnaire was used to collect information on participants’ sociodemographic characteristics, antibiotic knowledge, and health beliefs. Structural equation modelling (SEM) was employed to analyze the factors influencing residents’ intention to accept IVOS therapy. A total of 400 participants were included in the study. Overall, residents’ knowledge of antibiotics was moderate, with an average correct response rate of 60% across 10 questions. Perceived benefits (β = 0.59, p < 0.001) and self-efficacy (β = 0.27, p < 0.001) were positively associated with the intention to accept IVOS therapy in this cross-sectional study. The HBM variables explained 56.4% of the variance in behavioral intention.