Scholarlink

<p>Cancer-associated fibroblasts (CAFs) play an integral role in modulating the biological behavior of cancer cells through intricate and dynamic communication networks. However, the specific mechanism by which CAFs influence bladder cancer (BCa) remains elusive. This study integrated transcriptome data from multiple datasets to construct a gene ensemble associated with CAFs using a series of computational algorithms. This analysis identified two distinct molecular subtypes of BCa, characterized by varying levels of immune cell infiltration and immune-related features. CAMK4 was subsequently selected for further validation, revealing its role in enhancing the tumor-promoting functions of BCa, particularly in terms of proliferation, migration, invasion, and the induction of epithelial-mesenchymal transition (EMT). To sum up, the identified signature and its corresponding subtypes enable the identification of potential candidates for immunotherapy among BCa patients. Additionally, CAMK4 may emerge as a promising therapeutic target for BCa treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

In silico analysis and validation of the cancer-associated fibroblasts-related gene CAMK4 promotes bladder cancer progression

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月23日

查看全文
  • Xiaokang Su,
  • Yi Guo,
  • Youkong Li

摘要

Cancer-associated fibroblasts (CAFs) play an integral role in modulating the biological behavior of cancer cells through intricate and dynamic communication networks. However, the specific mechanism by which CAFs influence bladder cancer (BCa) remains elusive. This study integrated transcriptome data from multiple datasets to construct a gene ensemble associated with CAFs using a series of computational algorithms. This analysis identified two distinct molecular subtypes of BCa, characterized by varying levels of immune cell infiltration and immune-related features. CAMK4 was subsequently selected for further validation, revealing its role in enhancing the tumor-promoting functions of BCa, particularly in terms of proliferation, migration, invasion, and the induction of epithelial-mesenchymal transition (EMT). To sum up, the identified signature and its corresponding subtypes enable the identification of potential candidates for immunotherapy among BCa patients. Additionally, CAMK4 may emerge as a promising therapeutic target for BCa treatment.