Scholarlink

<p>The composition of intestinal gas, a metabolic product of the gut microbiota, may reflect the state of the intestinal environment. However, conventional gas measurement methods are challenging because of their high invasiveness. Therefore, we aimed to analyze the changes in intestinal gas composition and gut microbiota following prebiotic intervention using a novel system—that can non-invasively collect intestinal gas released during daily defecation. We propose a new index for intestinal environment evaluation based on intestinal gas and gut microbiota relationships. Healthy adults consumed inulin and galactooligosaccharides daily for 7 weeks. Intestinal gas was collected for 3 weeks before the intervention and during the last 3 weeks of the intervention. Fecal samples were collected in week 2 before the intervention and week 6 of the intervention. Following intervention, hydrogen and carbon dioxide gases increased significantly, whereas methanethiol decreased significantly. Although not significant, a decreasing trend in hydrogen sulfide was also observed. We proposed an “intestinal gas ratio index (fermentation-to-putrefaction gas ratio)”, demonstrating its strong correlation with dynamic changes in the gut microbiota, particularly the relative abundance of Japanese beneficial bacteria and sulfur-based gas-producing bacteria, and bacterial diversity. Overall, this index serves as a non-invasive functional marker for evaluating the intestinal environment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Novel index for assessing the intestinal environment in prebiotic-supplemented healthy adults via non-invasive gas analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月19日

查看全文
  • Ayano Hosokawa,
  • Haruna Matsui,
  • Shota Fujino,
  • Daiki Aoki,
  • Hitoaki Higuchi,
  • Katsunori Ishii,
  • Masayuki Oba,
  • Michihiro Mutoh,
  • Yuji Naito

摘要

The composition of intestinal gas, a metabolic product of the gut microbiota, may reflect the state of the intestinal environment. However, conventional gas measurement methods are challenging because of their high invasiveness. Therefore, we aimed to analyze the changes in intestinal gas composition and gut microbiota following prebiotic intervention using a novel system—that can non-invasively collect intestinal gas released during daily defecation. We propose a new index for intestinal environment evaluation based on intestinal gas and gut microbiota relationships. Healthy adults consumed inulin and galactooligosaccharides daily for 7 weeks. Intestinal gas was collected for 3 weeks before the intervention and during the last 3 weeks of the intervention. Fecal samples were collected in week 2 before the intervention and week 6 of the intervention. Following intervention, hydrogen and carbon dioxide gases increased significantly, whereas methanethiol decreased significantly. Although not significant, a decreasing trend in hydrogen sulfide was also observed. We proposed an “intestinal gas ratio index (fermentation-to-putrefaction gas ratio)”, demonstrating its strong correlation with dynamic changes in the gut microbiota, particularly the relative abundance of Japanese beneficial bacteria and sulfur-based gas-producing bacteria, and bacterial diversity. Overall, this index serves as a non-invasive functional marker for evaluating the intestinal environment.