Scholarlink

<p>We report a dual-modality microwave–optical platform for label-free differentiation of the stress-related hormonal biomarkers Cortisol and dehydroepiandrosterone (DHEA) in aqueous media. The approach combines resonant dielectric perturbation using a metastructure-based microwave stripline sensor operating in the 3–4&#xa0;GHz range with thermoelastic optical indicator microscopy in the 8–12&#xa0;GHz range for spatial visualization of microwave absorption. The resonant modality revealed distinct electrodynamic responses for the two biomarkers, exhibiting opposite trends in resonance amplitude and frequency shift with increasing concentration. Estimated limits of detection were 0.192&#xa0;mg/ml and 0.275&#xa0;mg/ml for Cortisol, and 0.302&#xa0;mg/ml and 0.117&#xa0;mg/ml for DHEA, depending on the readout parameter. Thermoelastic measurements provided complementary near-field mapping, with detection limits of 0.771&#xa0;mg/ml for Cortisol and 0.103&#xa0;mg/ml for DHEA. Unlike UV–Vis spectroscopy, which was limited by DHEA solubility constraints, microwave interrogation remained effective across the investigated range. These results demonstrate that multi-parameter microwave interrogation enables differentiable electrodynamic signatures of structurally distinct biomarkers without chemical functionalization, providing a proof-of-concept framework for label-free microwave biosensing.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dual-modality microwave–optical platform for label-free electrodynamic differentiation of cortisol and DHEA biomarkers

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月31日

查看全文
  • Tigran Abrahamyan,
  • Narek Nazaryan,
  • Nelli Babajanyan,
  • Artyom Movsisyan,
  • Hasmik Manukyan,
  • Billi Minasyan,
  • Khachatur Nerkararyan,
  • Kiejin Lee,
  • Arsen Babajanyan

摘要

We report a dual-modality microwave–optical platform for label-free differentiation of the stress-related hormonal biomarkers Cortisol and dehydroepiandrosterone (DHEA) in aqueous media. The approach combines resonant dielectric perturbation using a metastructure-based microwave stripline sensor operating in the 3–4 GHz range with thermoelastic optical indicator microscopy in the 8–12 GHz range for spatial visualization of microwave absorption. The resonant modality revealed distinct electrodynamic responses for the two biomarkers, exhibiting opposite trends in resonance amplitude and frequency shift with increasing concentration. Estimated limits of detection were 0.192 mg/ml and 0.275 mg/ml for Cortisol, and 0.302 mg/ml and 0.117 mg/ml for DHEA, depending on the readout parameter. Thermoelastic measurements provided complementary near-field mapping, with detection limits of 0.771 mg/ml for Cortisol and 0.103 mg/ml for DHEA. Unlike UV–Vis spectroscopy, which was limited by DHEA solubility constraints, microwave interrogation remained effective across the investigated range. These results demonstrate that multi-parameter microwave interrogation enables differentiable electrodynamic signatures of structurally distinct biomarkers without chemical functionalization, providing a proof-of-concept framework for label-free microwave biosensing.