<p>The wildfires that swept through Napa Valley in 2020 caused an estimated USD$3.7 billion economic loss to the grape and wine industry. The wines made from smoke-impacted grapes are often described as medicinal, smoky, and possessing a retronasal ashtray character. However, matrix differences among varieties and winemaking styles can impact smoke taint expression as well as the synergistic effects among the volatile phenols responsible for these off-flavors. Serial dilutions of non-impacted and impacted (intentionally smoked post-harvest) wines were used to create wines with differing levels of smoke impact for two wine regions (Napa and Lodi) and styles of Cabernet Sauvignon that were fermented and finished in stainless steel (SS) or subsequently aged in new oak barrels for 12 months. Gas chromatography–mass spectrometry (GC–MS) and liquid chromatography-triple quadrupole mass spectrometry (LC-QqQ-MS) were used to quantify free and total volatile phenols (VPs), and individual bound glycosides, respectively. Descriptive analysis using trained judges and Wine Cuality™ evaluations with wine experts were used to evaluate the sensory characteristics and overall quality of the wines, respectively. Generally, barrel-aged wines saw a decrease in the level of “ashy aftertaste” and smoke-related attributes for both Cabernet Sauvignon wines as compared to their stainless-steel counterparts. Wines with high levels of smoke impact received significantly lower quality ratings (<i>p</i> &lt; 0.05). Interestingly, wines with low levels of smoke-impact consistently received a slightly higher quality rating though not statistically significant when compared to their non-impacted counterparts. These findings contribute to our understanding of grape smoke exposure at different levels of taint and demonstrate the potential value of barrel aging to mitigate overall smoke perception in wine across these taint levels.</p>