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<p>To investigate the role of high-mobility group box 1 (HMGB1) in atrial fibrillation (AF) occurrence and prognosis among patients with heart failure with preserved ejection fraction (HFpEF). This study enrolled 276 HFpEF patients. Serum HMGB1 levels were measured. Logistic regression and Cox proportional hazards models were used to assess the risk factor for AF and all-cause mortality, respectively. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of HMGB1. HMGB1 levels were significantly higher in HFpEF patients with AF, and were further elevated in patients with persistent AF. Cox regression analysis revealed that elevated HMGB1 was associate with the increased all-cause mortality (HR = 1.953, 95% CI: 1.165–3.275, P = 0.011). ROC analysis for mortality prediction yielded an AUC of 0.897 (95% CI: 0.847–0.948), with an optimal cutoff of 16.75 pg/ml. Internal validation confirmed good stability and generalizability of the predictive model. HMGB1 is associated with AF and predicts all-cause mortality in HFpEF patients, serving as a potential biomarker for risk stratification and guiding targeted interventions. </p>

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HMGB1 is associated with atrial fibrillation and prognosis in heart failure with preserved ejection fraction

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Peipei Ge,
  • Juan Wang,
  • Aijuan Sun,
  • Weili Zhang

摘要

To investigate the role of high-mobility group box 1 (HMGB1) in atrial fibrillation (AF) occurrence and prognosis among patients with heart failure with preserved ejection fraction (HFpEF). This study enrolled 276 HFpEF patients. Serum HMGB1 levels were measured. Logistic regression and Cox proportional hazards models were used to assess the risk factor for AF and all-cause mortality, respectively. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of HMGB1. HMGB1 levels were significantly higher in HFpEF patients with AF, and were further elevated in patients with persistent AF. Cox regression analysis revealed that elevated HMGB1 was associate with the increased all-cause mortality (HR = 1.953, 95% CI: 1.165–3.275, P = 0.011). ROC analysis for mortality prediction yielded an AUC of 0.897 (95% CI: 0.847–0.948), with an optimal cutoff of 16.75 pg/ml. Internal validation confirmed good stability and generalizability of the predictive model. HMGB1 is associated with AF and predicts all-cause mortality in HFpEF patients, serving as a potential biomarker for risk stratification and guiding targeted interventions.