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<p>Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with progressive bile duct injury, inflammation, and fibrosis. Matrix metalloproteinases (MMPs) contribute to extracellular matrix remodeling but their circulating profile and clinical relevance in early-stage PBC remain incompletely defined. We characterized circulating MMPs in early-stage PBC and related them to non-invasive fibrosis and portal hemodynamics. Forty-six patients with early-stage PBC and 31 healthy controls were studied. Plasma MMP-2, -3, -7, -9, -10, and -26 were quantified by ELISA; liver stiffness was measured by point shear-wave elastography and portal flow indices by Doppler ultrasound. Compared with controls, PBC patients showed higher MMP-7 (<i>p</i> &lt; 0.0001), MMP-2 (<i>p</i> = 0.0007), and MMP-10 (<i>p</i> = 0.046). MMP-7 correlated with liver stiffness (<i>R</i> = 0.68, <i>p</i> &lt; 0.001) and demonstrated the highest discriminatory performance for significant fibrosis defined as LSM &gt; 5.56&#xa0;kPa (AUC = 0.800, <i>p</i> &lt; 0.001). In exploratory regression analyses, higher MMP-7 concentrations remained associated with significant fibrosis after adjustment for age, whereas APRI and FIB-4 did not show significant discriminatory performance in ROC analysis. Early-stage PBC is therefore associated with a distinct plasma MMP profile, and MMP-7 may serve as a practical biomarker of fibrogenesis, supporting its use for monitoring disease progression.</p>

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Circulating matrix metalloproteinase profile in early-stage primary biliary cholangitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月21日

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  • Magdalena Rogalska,
  • Sławomir Ławicki,
  • Agnieszka Błachnio-Zabielska,
  • Piotr Zabielski,
  • Kamila Roszczyc-Owsiejczuk,
  • Jacek Janica,
  • Aleksandra Andrzejuk,
  • Justyna Kryńska,
  • Maksymilian Lech,
  • Andrzej Dąbrowski,
  • Robert Flisiak,
  • Paweł Rogalski

摘要

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease with progressive bile duct injury, inflammation, and fibrosis. Matrix metalloproteinases (MMPs) contribute to extracellular matrix remodeling but their circulating profile and clinical relevance in early-stage PBC remain incompletely defined. We characterized circulating MMPs in early-stage PBC and related them to non-invasive fibrosis and portal hemodynamics. Forty-six patients with early-stage PBC and 31 healthy controls were studied. Plasma MMP-2, -3, -7, -9, -10, and -26 were quantified by ELISA; liver stiffness was measured by point shear-wave elastography and portal flow indices by Doppler ultrasound. Compared with controls, PBC patients showed higher MMP-7 (p < 0.0001), MMP-2 (p = 0.0007), and MMP-10 (p = 0.046). MMP-7 correlated with liver stiffness (R = 0.68, p < 0.001) and demonstrated the highest discriminatory performance for significant fibrosis defined as LSM > 5.56 kPa (AUC = 0.800, p < 0.001). In exploratory regression analyses, higher MMP-7 concentrations remained associated with significant fibrosis after adjustment for age, whereas APRI and FIB-4 did not show significant discriminatory performance in ROC analysis. Early-stage PBC is therefore associated with a distinct plasma MMP profile, and MMP-7 may serve as a practical biomarker of fibrogenesis, supporting its use for monitoring disease progression.