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<p>To compare oncological outcomes between HPV-positive and HPV-negative cervical cancer patients in a large Chinese multicenter cohort. This retrospective study included cervical squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma. Propensity score matching (PSM, 2:1) was used to balance baseline characteristics. Kaplan–Meier method and Cox proportional hazards regression were applied to compare 5-year overall survival (OS) and disease-free survival (DFS). The proportional hazards assumption was tested. Multicenter heterogeneity was adjusted using center stratification. Missing data were managed by complete-case analysis and multiple imputation sensitivity analysis. A total of 11,215 eligible patients were included. Before PSM, the HPV-positive group showed significantly better 5-year OS (92.3% vs. 84.3%, <i>P</i> &lt; 0.001) and DFS (88.0% vs. 79.6%, <i>P</i> &lt; 0.001) than the HPV-negative group. Multivariable Cox analysis confirmed HPV negativity as an independent risk factor for OS (HR = 1.545, 95%CI 1.091–2.188, <i>P</i> = 0.014) and DFS (HR = 1.556, 95%CI 1.212–1.997, <i>P</i> &lt; 0.001). After 2:1PSM, HPV-positive patients still had superior 5-year OS (88.4% vs. 84.3%, <i>P</i> = 0.004) and DFS (85.3% vs. 79.6%, <i>P</i> &lt; 0.001). Among 7,998 patients who underwent radical surgery, similar results were observed before and after PSM. HPV-negative status is associated with inferior 5-year OS and DFS and serves as an independent adverse prognostic factor in cervical cancer, including patients treated with radical surgery.</p>

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The prognostic value of different HPV infection statuses in cervical cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月14日

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  • Yu Sun,
  • Ping Liu,
  • Mei Ji,
  • Min Hao,
  • Qinlan Luo,
  • Zhumei Cui,
  • Xiaoyan Xin,
  • Donglin Li,
  • Mingwei Li,
  • Weili Li,
  • Chunlin Chen

摘要

To compare oncological outcomes between HPV-positive and HPV-negative cervical cancer patients in a large Chinese multicenter cohort. This retrospective study included cervical squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma. Propensity score matching (PSM, 2:1) was used to balance baseline characteristics. Kaplan–Meier method and Cox proportional hazards regression were applied to compare 5-year overall survival (OS) and disease-free survival (DFS). The proportional hazards assumption was tested. Multicenter heterogeneity was adjusted using center stratification. Missing data were managed by complete-case analysis and multiple imputation sensitivity analysis. A total of 11,215 eligible patients were included. Before PSM, the HPV-positive group showed significantly better 5-year OS (92.3% vs. 84.3%, P < 0.001) and DFS (88.0% vs. 79.6%, P < 0.001) than the HPV-negative group. Multivariable Cox analysis confirmed HPV negativity as an independent risk factor for OS (HR = 1.545, 95%CI 1.091–2.188, P = 0.014) and DFS (HR = 1.556, 95%CI 1.212–1.997, P < 0.001). After 2:1PSM, HPV-positive patients still had superior 5-year OS (88.4% vs. 84.3%, P = 0.004) and DFS (85.3% vs. 79.6%, P < 0.001). Among 7,998 patients who underwent radical surgery, similar results were observed before and after PSM. HPV-negative status is associated with inferior 5-year OS and DFS and serves as an independent adverse prognostic factor in cervical cancer, including patients treated with radical surgery.