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<p>In this study, low- and high-irradiance phototherapies were compared to determine the optimal irradiance for treating non-hemolytic neonatal jaundice. This multicenter, prospective, randomized controlled trial included full-term infants born between April 2017 and January 2022 who were hospitalized for neonatal jaundice. Participants were divided into low-irradiance (low group) and high-irradiance (high group) treatment arms. The primary outcome was the retreatment rate. A total of 104 infants (52 in each group) were included. Retreatment rates were not significantly different between the two groups (12% vs. 4%, <i>p</i> = 0.141). Only a few infants who required phototherapy after 72 h of birth needed retreatment (low group, 3%; high group, 0%). Considering the potential side effects of phototherapy, initiating treatment at low irradiance may be appropriate, particularly for infants aged &gt;72 h. Clinical trial registry and registration number This trial was registered to the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; <a href="http://www.umin.ac.jp">http://www.umin.ac.jp</a>.) on October 28, 2016. Registration number: UMIN000024352</p>

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Comparison of the effects of low-irradiance and high-irradiance phototherapy on non-hemolytic neonatal jaundice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月26日

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  • Norika Mamiya,
  • Yoshiaki Sato,
  • Kazuhiro Horiba,
  • Manabu Ino,
  • Marei Omori,
  • Shinsuke Jinno,
  • Yukako Muramatsu,
  • Yuichiro Sugiyama,
  • Ryosuke Miura,
  • Kazuto Ueda,
  • Akihiro Hirakawa,
  • Ryo Kitabayashi,
  • Hideki Muramatsu,
  • Jun-ichi Kawada,
  • Hiroyuki Kidokoro,
  • Yoshiyuki Takahashi,
  • Makoto Oshiro,
  • Maki Kondou,
  • Yuichi Kato,
  • Tetsuo Hattori,
  • Michio Suzuki,
  • Hikaru Yamamoto,
  • Yoshihiro Tanahashi,
  • Shin Hoshino

摘要

In this study, low- and high-irradiance phototherapies were compared to determine the optimal irradiance for treating non-hemolytic neonatal jaundice. This multicenter, prospective, randomized controlled trial included full-term infants born between April 2017 and January 2022 who were hospitalized for neonatal jaundice. Participants were divided into low-irradiance (low group) and high-irradiance (high group) treatment arms. The primary outcome was the retreatment rate. A total of 104 infants (52 in each group) were included. Retreatment rates were not significantly different between the two groups (12% vs. 4%, p = 0.141). Only a few infants who required phototherapy after 72 h of birth needed retreatment (low group, 3%; high group, 0%). Considering the potential side effects of phototherapy, initiating treatment at low irradiance may be appropriate, particularly for infants aged >72 h. Clinical trial registry and registration number This trial was registered to the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; http://www.umin.ac.jp.) on October 28, 2016. Registration number: UMIN000024352