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<p>In recent years, crystalline porous zeolite materials have been extensively investigated owing to their distinct characteristics, such as high surface area, pore volume, size, and thermal stability. In this work, 500&#xa0;nm to 1&#xa0;μm sized thermally stable cobalt-supported zeolite 4&#xa0;A was developed via impregnation method, employed as an efficient and reusable catalyst in synthesizing novel thiosemicarbazide and 1,2,4 triazole derivatives using Co-Zeolite 4&#xa0;A in ethanol: water (1:1) as a green solvent, and found most active among Ni and Fe-supported Zeolite 4&#xa0;A, with 89% yield. FT-IR, XRD, and BET data revealed characteristic metal-support interactions, crystalline domains, and reduction in surface area (10.1 to 9.4 m<sup>2</sup>/g), confirming successful cobalt incorporation and governing its catalytic activity. The catalyst has maintained its efficacy over five reaction cycles. The anticancer activity was meticulously evaluated with most potent 3,5-bis trifluoromethyl 1,2,4 triazole 4c, displayed IC<sub>50</sub> 8.74 µM and 29.51 µM against HeLa and PC3 cancer cell lines. In silico docking indicated that compound 4c strongly interacted with the tumor suppressor protein p21, and DFT studies confirmed the chemical reactivity of compounds 3a-3c. This synthetic approach offers high yields, faster reaction times, robust and reusable catalyst, and environmentally sustainable platform for organic transformations with therapeutic potential.</p>

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Facile Cobalt-supported Zeolite 4 A as ecofriendly catalyst to prepare 2-Furyl- hydrazine-1-carbothioamides and 1,2,4 Triazole-3-thiones with anticancer investigation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月19日

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  • Asiya Farheen,
  • Asia Naz Awan,
  • Abdul Hameed,
  • Syed Fakhar Alam

摘要

In recent years, crystalline porous zeolite materials have been extensively investigated owing to their distinct characteristics, such as high surface area, pore volume, size, and thermal stability. In this work, 500 nm to 1 μm sized thermally stable cobalt-supported zeolite 4 A was developed via impregnation method, employed as an efficient and reusable catalyst in synthesizing novel thiosemicarbazide and 1,2,4 triazole derivatives using Co-Zeolite 4 A in ethanol: water (1:1) as a green solvent, and found most active among Ni and Fe-supported Zeolite 4 A, with 89% yield. FT-IR, XRD, and BET data revealed characteristic metal-support interactions, crystalline domains, and reduction in surface area (10.1 to 9.4 m2/g), confirming successful cobalt incorporation and governing its catalytic activity. The catalyst has maintained its efficacy over five reaction cycles. The anticancer activity was meticulously evaluated with most potent 3,5-bis trifluoromethyl 1,2,4 triazole 4c, displayed IC50 8.74 µM and 29.51 µM against HeLa and PC3 cancer cell lines. In silico docking indicated that compound 4c strongly interacted with the tumor suppressor protein p21, and DFT studies confirmed the chemical reactivity of compounds 3a-3c. This synthetic approach offers high yields, faster reaction times, robust and reusable catalyst, and environmentally sustainable platform for organic transformations with therapeutic potential.