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<p>Alcohol consumption is recognized as a risk factor for oropharyngeal cancer. However, its role in oral human papillomavirus (HPV) infection among people living with HIV (PLWH) remains unclear. This cross-sectional study analyzed baseline data from 699 men living with HIV (MLWH) enrolled in the multicenter ULACNet-201 trial (NCT04255849) to assess oral HPV infection by drinking behavior, examine the association between alcohol consumption and HPV infection, exploring smoking as a potential effect modifier. Oral gargle specimens were tested for high-risk (HR-HPV) and low-risk (LR-HPV) HPV genotypes using SPF10 PCR-DEIA-LiPA25. Logistic regression estimated adjusted odds ratios (ORs, 95% CIs) controlling for key covariates and explored heterogeneity by smoking status. Alcohol use in the past month was reported by 76.4% of participants, with 6% classified as heavy drinkers and 27% as binge drinkers. Oral HPV infection was similar between drinkers and nondrinkers (27.7% vs. 28.5%), with comparable rates for HR-HPV (11% vs. 10.9%) and LR-HPV (18.7% vs. 19.7%). Alcohol consumption was not associated with HR-HPV overall, and exploratory analysis found no evidence of effect modification by smoking status. A possible interaction between alcohol consumption and smoking status was observed for LR-HPV, but these findings should be interpreted cautiously. Further longitudinal studies are needed.</p>

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Alcohol consumption and oral human papillomavirus infection among men living with HIV: a cross-sectional study from the ULACNet 201 trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月29日

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  • Anna Beltrame,
  • Luisa L. Villa,
  • Eduardo Lazcano-Ponce,
  • Jorge Santana-Bagur,
  • Betania Allen-Leigh,
  • Alejandra J. Portillo-Romero,
  • Vikrant V. Sahasrabuddhe,
  • Margaret G. House,
  • Emma Brofsky,
  • Lenice Galan de Paula,
  • Roberto Carvalho da Silva,
  • Wenyi Fan,
  • Michael J. Schell,
  • Julie Rathwell,
  • Kimberly Isaacs-Soriano,
  • Caique Mello,
  • Grant B. Ellsworth,
  • Timothy Wilkin,
  • Anna R. Giuliano

摘要

Alcohol consumption is recognized as a risk factor for oropharyngeal cancer. However, its role in oral human papillomavirus (HPV) infection among people living with HIV (PLWH) remains unclear. This cross-sectional study analyzed baseline data from 699 men living with HIV (MLWH) enrolled in the multicenter ULACNet-201 trial (NCT04255849) to assess oral HPV infection by drinking behavior, examine the association between alcohol consumption and HPV infection, exploring smoking as a potential effect modifier. Oral gargle specimens were tested for high-risk (HR-HPV) and low-risk (LR-HPV) HPV genotypes using SPF10 PCR-DEIA-LiPA25. Logistic regression estimated adjusted odds ratios (ORs, 95% CIs) controlling for key covariates and explored heterogeneity by smoking status. Alcohol use in the past month was reported by 76.4% of participants, with 6% classified as heavy drinkers and 27% as binge drinkers. Oral HPV infection was similar between drinkers and nondrinkers (27.7% vs. 28.5%), with comparable rates for HR-HPV (11% vs. 10.9%) and LR-HPV (18.7% vs. 19.7%). Alcohol consumption was not associated with HR-HPV overall, and exploratory analysis found no evidence of effect modification by smoking status. A possible interaction between alcohol consumption and smoking status was observed for LR-HPV, but these findings should be interpreted cautiously. Further longitudinal studies are needed.