Scholarlink

<p>Urinary tract infection (UTI) is a common bacterial infection among people living with HIV (PLWHIV) and can cause complications, particularly due to antimicrobial resistance. Data on UTIs among PLWHIV in Ethiopia are limited. This study assessed the bacterial profile, antimicrobial susceptibility, and associated factors of UTIs among 255 PLWHIV attending the ART outpatient clinic at Debre Markos Comprehensive Specialized Hospital from March to June 2025. Clean-catch midstream urine samples were inoculated on MacConkey and blood agar to identify pathogens, and antimicrobial susceptibility tested by Kirby–Bauer disk diffusion method. Statistical significance was set at <i>p</i> ≤ 0.05 with 95% confidence intervals. UTIs were identified in 28 participants (11%), with <i>E. coli</i> (46.4%), <i>S. aureus</i> (21.4%), and <i>P. aeruginosa</i> (14.3%) predominating. Female sex (AOR = 2.48; 95% CI 1.45–6.27; <i>p</i> = 0.010), HIV RNA &gt; 1000 copies/mL (AOR = 6.30; 95% CI 4.52–14.61; <i>p</i> = 0.001), CD4 +  &lt; 200 cells/mm<sup>3</sup> (AOR = 3.17; 95% CI 1.14–9.52; <i>p</i> = 0.028), and being symptomatic (AOR = 3.80; 95% CI 1.63–8.74; <i>p</i> = 0.024) were significantly associated with UTIs. The multidrug-resistant prevalence was 17.9%, highlighting the need for strengthened diagnostics, susceptibility-guided therapy, routine screening, and PLWHIV education on perineal hygiene to improve management and limit antimicrobial resistance.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bacterial profile, antimicrobial susceptibility, and associated factors of urinary tract infection among people living with HIV at Debre Markos Comprehensive Specialized Hospital, Ethiopia

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月16日

查看全文
  • Lijalem Shimelis,
  • Adane Adugna,
  • Abeba Mengist

摘要

Urinary tract infection (UTI) is a common bacterial infection among people living with HIV (PLWHIV) and can cause complications, particularly due to antimicrobial resistance. Data on UTIs among PLWHIV in Ethiopia are limited. This study assessed the bacterial profile, antimicrobial susceptibility, and associated factors of UTIs among 255 PLWHIV attending the ART outpatient clinic at Debre Markos Comprehensive Specialized Hospital from March to June 2025. Clean-catch midstream urine samples were inoculated on MacConkey and blood agar to identify pathogens, and antimicrobial susceptibility tested by Kirby–Bauer disk diffusion method. Statistical significance was set at p ≤ 0.05 with 95% confidence intervals. UTIs were identified in 28 participants (11%), with E. coli (46.4%), S. aureus (21.4%), and P. aeruginosa (14.3%) predominating. Female sex (AOR = 2.48; 95% CI 1.45–6.27; p = 0.010), HIV RNA > 1000 copies/mL (AOR = 6.30; 95% CI 4.52–14.61; p = 0.001), CD4 +  < 200 cells/mm3 (AOR = 3.17; 95% CI 1.14–9.52; p = 0.028), and being symptomatic (AOR = 3.80; 95% CI 1.63–8.74; p = 0.024) were significantly associated with UTIs. The multidrug-resistant prevalence was 17.9%, highlighting the need for strengthened diagnostics, susceptibility-guided therapy, routine screening, and PLWHIV education on perineal hygiene to improve management and limit antimicrobial resistance.