Scholarlink

<p>People with severe mental disorders (SMD) face higher hepatitis C virus (HCV) infection risks and lower treatment adherence compared to the general population. Traditional care pathways often fail due to fragmented coordination and patient-related barriers. This study evaluates the feasibility and acceptability of an individualized nurse navigation program (NNP) designed to facilitate adherence to medical appointments and pharmacological treatment in this population. A feasibility randomized open parallel trial was conducted. The intervention simplified the clinical pathway through intensive nursing support (phone reminders, in-person meetings, home visits) and appointment accompaniment. Primary outcomes included recruitment, retention, refusal rates, cure rate defined as undetectable HCV RNA at 12 weeks post-treatment, and identification of barriers. From 1,916 assessed individuals, 20 were eligible and 13 finally randomized (65% participation, refusal rate 35%). Overall, 69% (9/13) achieved a cure. Notably, the average cure time was nearly 11 months, indicating that standard 6-month follow-up is insufficient. Key facilitators included institutional residency and competent caregivers, while barriers included symptom-related non-attendance and system-level delays, such as deferred treatment prescription by gastroenterologists. The NNP is feasible and enhances HCV outcomes in SMD populations. Definitive trials require extended follow-up periods of 24 months and larger multicenter samples.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A nurse navigator program for the management of hepatitis C virus in patients with severe mental disorder. A feasibility trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月13日

查看全文
  • Casta Quemada,
  • Celia Martí-García,
  • María Magdalena Hurtado,
  • José Miguel Morales-Asencio

摘要

People with severe mental disorders (SMD) face higher hepatitis C virus (HCV) infection risks and lower treatment adherence compared to the general population. Traditional care pathways often fail due to fragmented coordination and patient-related barriers. This study evaluates the feasibility and acceptability of an individualized nurse navigation program (NNP) designed to facilitate adherence to medical appointments and pharmacological treatment in this population. A feasibility randomized open parallel trial was conducted. The intervention simplified the clinical pathway through intensive nursing support (phone reminders, in-person meetings, home visits) and appointment accompaniment. Primary outcomes included recruitment, retention, refusal rates, cure rate defined as undetectable HCV RNA at 12 weeks post-treatment, and identification of barriers. From 1,916 assessed individuals, 20 were eligible and 13 finally randomized (65% participation, refusal rate 35%). Overall, 69% (9/13) achieved a cure. Notably, the average cure time was nearly 11 months, indicating that standard 6-month follow-up is insufficient. Key facilitators included institutional residency and competent caregivers, while barriers included symptom-related non-attendance and system-level delays, such as deferred treatment prescription by gastroenterologists. The NNP is feasible and enhances HCV outcomes in SMD populations. Definitive trials require extended follow-up periods of 24 months and larger multicenter samples.