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<p>Tuberculosis (TB) is an infectious complication of hematopoietic cell transplantation (HCT). There is a paucity of data on TB after HCT. Here we present the data from a low/low-intermediate TB-burden country. This was a Retrospective analysis of adult patients who developed TB after HCT. Seventeen patients were identified, 9 (52.9%) females, the median age at TB 44&#xa0;years. Five (29.4%) patients underwent auto-HCT, 12 (70.6%) allo-HCT, translating into the relative frequency of TB of 0.171% for allo-HCT, and 0.063% for auto-HCT. The median time from HCT to TB was 431&#xa0;days (range, 5–973). All patients had pulmonary TB. Bacteriologically confirmed TB was diagnosed in 13 (76.5%) patients; drug susceptibility testing was performed in 3/13 (23.1%). The median duration of treatment was 6&#xa0;months. Twelve out of 13 evaluable patients (92.3%) obtained treatment success. With a median follow-up of 48&#xa0;months (95%CI 19–95) 1-year cumulative incidence of TB-associated death was 6.7% (95%CI 0.9–40.8%). To conclude TB is a very rare infectious complication of HCT. Most frequently TB develops late after HCT. The primary site involved is the lung with no extrapulmonary TB identified in the current analysis. TB can still result in the death of the affected patient.</p>

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Multicenter retrospective analysis by the Polish Adult Leukemia Group on tuberculosis occurrence and outcomes after hematopoietic cell transplantation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月11日

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  • Joanna Drozd-Sokołowska,
  • Anna Waszczuk-Gajda,
  • Elżbieta Sienkiewicz,
  • Agnieszka Piekarska,
  • Łukasz Bołkun,
  • Barbara Nasiłowska-Adamska,
  • Magdalena Tormanowska,
  • Joanna Kujawska,
  • Małgorzata Sobczyk-Kruszelnicka,
  • Paweł Szwedyk,
  • Justyna Rybka,
  • Joanna Romejko-Jarosińska,
  • Anna Kopińska,
  • Mariola Sędzimirska,
  • Izabela Dereń-Wagemann,
  • Jarosław Dybko,
  • Małgorzata Proboszcz,
  • Agnieszka Tomaszewska,
  • Przemysław Biecek,
  • Grzegorz Basak,
  • Sebastian Giebel,
  • Lidia Gil

摘要

Tuberculosis (TB) is an infectious complication of hematopoietic cell transplantation (HCT). There is a paucity of data on TB after HCT. Here we present the data from a low/low-intermediate TB-burden country. This was a Retrospective analysis of adult patients who developed TB after HCT. Seventeen patients were identified, 9 (52.9%) females, the median age at TB 44 years. Five (29.4%) patients underwent auto-HCT, 12 (70.6%) allo-HCT, translating into the relative frequency of TB of 0.171% for allo-HCT, and 0.063% for auto-HCT. The median time from HCT to TB was 431 days (range, 5–973). All patients had pulmonary TB. Bacteriologically confirmed TB was diagnosed in 13 (76.5%) patients; drug susceptibility testing was performed in 3/13 (23.1%). The median duration of treatment was 6 months. Twelve out of 13 evaluable patients (92.3%) obtained treatment success. With a median follow-up of 48 months (95%CI 19–95) 1-year cumulative incidence of TB-associated death was 6.7% (95%CI 0.9–40.8%). To conclude TB is a very rare infectious complication of HCT. Most frequently TB develops late after HCT. The primary site involved is the lung with no extrapulmonary TB identified in the current analysis. TB can still result in the death of the affected patient.