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<p><i>Zoanthus sansibaricus</i> is a marine invertebrate native to the Indian and North Pacific Oceans. A chemical investigation of <i>Z. sansibaricus</i>, cultured in an aquafarm, led to the isolation of two new zoanthamine derivatives, named 3<i>β</i>-hydroxyzoanthamine (1) and 3<i>α</i>-hydroxynorzoanthaminone (2), along with five known derivatives (3‒7). Their structures were elucidated through quantum chemical calculations and a detailed analysis of spectroscopic data, including mass, IR, and NMR spectra. New compounds 1 and 2 represent additional examples of the oxidation of zoanthamine derivatives. The potential photoprotective effect of all isolated alkaloids (1‒7) was evaluated against UVA-induced damage in human dermal fibroblasts. Among the tested compounds, only 26-norzoanthamine (4) significantly attenuated UVA-induced oxidative stress. Notably, this antioxidant activity did not translate into sustained cell viability protection at 72 hours post-irradiation, suggesting that the photoprotective mechanism of compound 4 is limited to acute oxidative stress attenuation.</p>

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Photoprotective zoanthamine derivatives from the cultured zoantharian zoanthus sansibaricus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月1日

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  • Yih-Fung Chen,
  • Shu-Rong Chen,
  • Yi Chen,
  • Ci Chen Teh,
  • Tzu-Yi Ke,
  • Yu-Chi Lin,
  • Yuan-Bin Cheng

摘要

Zoanthus sansibaricus is a marine invertebrate native to the Indian and North Pacific Oceans. A chemical investigation of Z. sansibaricus, cultured in an aquafarm, led to the isolation of two new zoanthamine derivatives, named 3β-hydroxyzoanthamine (1) and 3α-hydroxynorzoanthaminone (2), along with five known derivatives (3‒7). Their structures were elucidated through quantum chemical calculations and a detailed analysis of spectroscopic data, including mass, IR, and NMR spectra. New compounds 1 and 2 represent additional examples of the oxidation of zoanthamine derivatives. The potential photoprotective effect of all isolated alkaloids (1‒7) was evaluated against UVA-induced damage in human dermal fibroblasts. Among the tested compounds, only 26-norzoanthamine (4) significantly attenuated UVA-induced oxidative stress. Notably, this antioxidant activity did not translate into sustained cell viability protection at 72 hours post-irradiation, suggesting that the photoprotective mechanism of compound 4 is limited to acute oxidative stress attenuation.