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<p>Norovirus is a leading cause of acute gastroenteritis (AGE) worldwide, affecting all age groups. In the present study, we investigated fecal samples from medically attended AGE patients received from ten Brazilian states collected during 2023 and 2024. Norovirus GI and GII were detected and quantified using RT-qPCR, and norovirus-positive samples underwent genotyping through sequencing the ORF1/2 junction region. During the two-year period, norovirus prevalence was 22.5%. GII genotypes were predominant, accounting for 85.6% of the genotyped samples. By genotyping, we detected the circulation of 19 norovirus genotypes, of which the emergence of GII.17[P17] in 2023 and its predominance in 2024. Comparison of cycle threshold (Ct) values indicated that the median viral load was significantly higher for norovirus GII.17 compared to GII.4 (20.9 and 22.3, respectively (<i>p</i> = 0.0493). Additionally, we showed that GII.17 patients were older compared to GII.4 patients. Our study is the first in South America to demonstrate replacement of the previous dominant genotype (GII.4 Sydney[P16]) to GII.17[P17] in 2024, currently disseminated worldwide.</p>

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Emergence and predominance of GII.17[P17] noroviruses in Brazil, 2023–2024

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月25日

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  • Fábio Correia Malta,
  • Mateus de Souza Mello,
  • Ighor Arantes,
  • Juliana da Silva Ribeiro de Andrade,
  • Alexandre Madi Fialho,
  • Gabriel Assad Baduy,
  • Rafael Brandão Varella,
  • Maria Angelica Arpon Marandino Guimarães,
  • Fernanda Marcicano Burlandy,
  • Tulio Machado Fumian

摘要

Norovirus is a leading cause of acute gastroenteritis (AGE) worldwide, affecting all age groups. In the present study, we investigated fecal samples from medically attended AGE patients received from ten Brazilian states collected during 2023 and 2024. Norovirus GI and GII were detected and quantified using RT-qPCR, and norovirus-positive samples underwent genotyping through sequencing the ORF1/2 junction region. During the two-year period, norovirus prevalence was 22.5%. GII genotypes were predominant, accounting for 85.6% of the genotyped samples. By genotyping, we detected the circulation of 19 norovirus genotypes, of which the emergence of GII.17[P17] in 2023 and its predominance in 2024. Comparison of cycle threshold (Ct) values indicated that the median viral load was significantly higher for norovirus GII.17 compared to GII.4 (20.9 and 22.3, respectively (p = 0.0493). Additionally, we showed that GII.17 patients were older compared to GII.4 patients. Our study is the first in South America to demonstrate replacement of the previous dominant genotype (GII.4 Sydney[P16]) to GII.17[P17] in 2024, currently disseminated worldwide.