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<p>Rheumatoid arthritis (RA) is a persistent autoimmune disease stimulated by a sophisticated system of proinflammatory cytokines such as TNF-α and IL -17. They contribute significantly to the maintenance of inflammation and mediation of joint damage. The current study aimed to examine the relationship between serum concentrations of TNF-α, IL-17&#xa0;A, and IL-17&#xa0;F and disease activity in Yemeni RA patients. A case-control study was carried out on 101 RA patients and 80 healthy controls (HCs) matched for age and sex. The serum concentration of TNF-α, IL-17&#xa0;A, and IL-17&#xa0;F was determined through an enzyme-linked immunosorbent assay (ELISA). Other hematological, inflammatory parameters and serological tests were also assessed. TNF-α, IL-17&#xa0;A and IL-17&#xa0;F serum levels were significantly elevated in RA patients than in HCs (<i>P</i> &lt; 0.001) and had a positive correlation with disease activity in RA groups (<i>P</i> &lt; 0.001). Furthermore, a significant positive correlation between levels of TNF-α, IL-17&#xa0;A, and IL-17&#xa0;F and the DAS28. The ROC analysis revealed that all the three cytokines TNF-α, IL-17&#xa0;A, and IL-17&#xa0;F were effective in distinguishing between RA patients and HCs, with TNF-α having the highest diagnostic accuracy. To define moderate to high disease activity, IL-17&#xa0;A demonstrated the best individual quality, whereas TNF-α and IL-17&#xa0;F demonstrated moderate quality. Interaction of the cytokines improved the diagnostic value as both TNF-α and IL-17&#xa0;A combination and triple combination of TNF-α, IL-17&#xa0;A and IL17F which supports the benefits of multiplex cytokine testing in RA activity testing as well as discrimination of moderate to high activity RA.</p>

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Association of serum TNF-α, IL-17 A, and IL-17 F levels with disease activity in Yemeni patients with rheumatoid arthritis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月13日

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  • Amr A. Saleh,
  • Anwar K. Al-Madhaji,
  • Hassan A. Al-Shamahy,
  • Raja M Al-Haimi,
  • Marwan K. Saeed

摘要

Rheumatoid arthritis (RA) is a persistent autoimmune disease stimulated by a sophisticated system of proinflammatory cytokines such as TNF-α and IL -17. They contribute significantly to the maintenance of inflammation and mediation of joint damage. The current study aimed to examine the relationship between serum concentrations of TNF-α, IL-17 A, and IL-17 F and disease activity in Yemeni RA patients. A case-control study was carried out on 101 RA patients and 80 healthy controls (HCs) matched for age and sex. The serum concentration of TNF-α, IL-17 A, and IL-17 F was determined through an enzyme-linked immunosorbent assay (ELISA). Other hematological, inflammatory parameters and serological tests were also assessed. TNF-α, IL-17 A and IL-17 F serum levels were significantly elevated in RA patients than in HCs (P < 0.001) and had a positive correlation with disease activity in RA groups (P < 0.001). Furthermore, a significant positive correlation between levels of TNF-α, IL-17 A, and IL-17 F and the DAS28. The ROC analysis revealed that all the three cytokines TNF-α, IL-17 A, and IL-17 F were effective in distinguishing between RA patients and HCs, with TNF-α having the highest diagnostic accuracy. To define moderate to high disease activity, IL-17 A demonstrated the best individual quality, whereas TNF-α and IL-17 F demonstrated moderate quality. Interaction of the cytokines improved the diagnostic value as both TNF-α and IL-17 A combination and triple combination of TNF-α, IL-17 A and IL17F which supports the benefits of multiplex cytokine testing in RA activity testing as well as discrimination of moderate to high activity RA.