Scholarlink

<p>Percutaneous coronary intervention (PCI) is a common minimally-invasive procedure for treating coronary artery stenosis. However, 10% of patients with non-complex lesions experience restenosis within five years of initial PCI. Wall shear stress (WSS) is a physiological marker that provides additional predictive value for restenosis. The ability to estimate WSS during PCI could identify patients at high risk for restenosis. In order to assess the accuracy of intravascular ultrasound WSS imaging in coronary geometries, a high-frequency linear array was used to image three unique coronary phantom geometries before stenting and with partially- and fully-expanded stents. Acquired 2D WSS images were registered and compared with 3D in silico results. Finally, 3D images were acquired in a single geometry using a newly-developed intravascular ultrasound matrix array. Ultrasound-derived flow velocity maps demonstrated a mean absolute percentage error of 13.04 ± 4.82% relative to simulations, with a mean correlation of 81.91 ± 14.59%. Segments with partially-expanded stents exhibited decreased mean WSS (0.0800 ± 0.0233&#xa0;Pa vs. 0.1328 ± 0.0265&#xa0;Pa, <i>p</i> = 0.0479) and increased WSS spatial variance (0.0038 ± 0.0011 Pa<sup>2</sup> vs. 0.00069 ± 0.000090 Pa<sup>2</sup>, <i>p</i> = 0.0546) compared to segments with fully expanded stents. Accurate WSS imaging during PCI could stratify restenosis risk and inform long-term coronary modeling (i.e. digital twin system).</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Intravascular ultrasound wall shear stress imaging in stented coronary arteries with ultrafast Doppler

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月9日

查看全文
  • Travis C. Singh,
  • Stephan Strassle Rojas,
  • Imran Shah,
  • Jimena Martín Tempestti,
  • Alessandro Veneziani,
  • Brooks D. Lindsey

摘要

Percutaneous coronary intervention (PCI) is a common minimally-invasive procedure for treating coronary artery stenosis. However, 10% of patients with non-complex lesions experience restenosis within five years of initial PCI. Wall shear stress (WSS) is a physiological marker that provides additional predictive value for restenosis. The ability to estimate WSS during PCI could identify patients at high risk for restenosis. In order to assess the accuracy of intravascular ultrasound WSS imaging in coronary geometries, a high-frequency linear array was used to image three unique coronary phantom geometries before stenting and with partially- and fully-expanded stents. Acquired 2D WSS images were registered and compared with 3D in silico results. Finally, 3D images were acquired in a single geometry using a newly-developed intravascular ultrasound matrix array. Ultrasound-derived flow velocity maps demonstrated a mean absolute percentage error of 13.04 ± 4.82% relative to simulations, with a mean correlation of 81.91 ± 14.59%. Segments with partially-expanded stents exhibited decreased mean WSS (0.0800 ± 0.0233 Pa vs. 0.1328 ± 0.0265 Pa, p = 0.0479) and increased WSS spatial variance (0.0038 ± 0.0011 Pa2 vs. 0.00069 ± 0.000090 Pa2, p = 0.0546) compared to segments with fully expanded stents. Accurate WSS imaging during PCI could stratify restenosis risk and inform long-term coronary modeling (i.e. digital twin system).