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<p>The current study of the biosynthesized Sm-AuNPs reveals a SPR peak at 554&#xa0;nm indicating reduction of gold chloride to gold nanoparticles (Sm-AuNPs). Fourier Infrared Spectroscopy revealed that different bioactive compounds of bark extract were involved in reduction and stabilization of Sm-AuNPs. Transmission Electron Microscopy and EDX analysis of Sm-AuNPs reveals that the nanoparticles spherical in shape. The Sm-AuNPs are poly-dispersed in nature, with a poly-disperse index about 0.310 and high negative zeta potential value of -62.5 mV. The Sm-AuNPs reveals excellent antioxidant, antibacterial, anticancer activities and anti-viral properties. The results revealed that the Sm-AuNPs have an excellent antibacterial activity when compared with standard antibiotics while they also reveal a significant antioxidant activity. The anticancer studies on SKOV ovarian cancer cell line by Sm-AuNPs was carried by MTT assay, reveals that IC<sub>50</sub> value was 64.19&#xa0;µg/ml and the apoptotic cells were detected by Dual fluorescence assay. Apart from the above studies, the antiviral efficacy of Sm-AuNPs on New Castle Disease (NDV) was carried out in embryonated chicken eggs, reveals that the Sm-AuNPs have very good and considerable antiviral properties. The green synthesized Sm-AuNPs can useful as future therapeutic agents to control cancer and NDV effectively.</p>

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Multifaceted gold vanoparticles by bark extract of Sweetinia mahagoni and their potential antimicrobial, antioxidant, anticancer and antiviral applications

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月23日

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  • Venkata Subbaiah Kotakadi,
  • Susmila Aparna Gaddam,
  • Lakshmi Kavitha Kommalapati,
  • Siva Gayathri Velakanti,
  • Alapati Phanidhara,
  • Devaraju Thangellamudi,
  • Hema Masarapu,
  • Enyew Amare Zereffa

摘要

The current study of the biosynthesized Sm-AuNPs reveals a SPR peak at 554 nm indicating reduction of gold chloride to gold nanoparticles (Sm-AuNPs). Fourier Infrared Spectroscopy revealed that different bioactive compounds of bark extract were involved in reduction and stabilization of Sm-AuNPs. Transmission Electron Microscopy and EDX analysis of Sm-AuNPs reveals that the nanoparticles spherical in shape. The Sm-AuNPs are poly-dispersed in nature, with a poly-disperse index about 0.310 and high negative zeta potential value of -62.5 mV. The Sm-AuNPs reveals excellent antioxidant, antibacterial, anticancer activities and anti-viral properties. The results revealed that the Sm-AuNPs have an excellent antibacterial activity when compared with standard antibiotics while they also reveal a significant antioxidant activity. The anticancer studies on SKOV ovarian cancer cell line by Sm-AuNPs was carried by MTT assay, reveals that IC50 value was 64.19 µg/ml and the apoptotic cells were detected by Dual fluorescence assay. Apart from the above studies, the antiviral efficacy of Sm-AuNPs on New Castle Disease (NDV) was carried out in embryonated chicken eggs, reveals that the Sm-AuNPs have very good and considerable antiviral properties. The green synthesized Sm-AuNPs can useful as future therapeutic agents to control cancer and NDV effectively.